The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function
Michael F. Egan,Masami Kojima,Masami Kojima,Joseph H. Callicott,Terry E. Goldberg,Bhaskar Kolachana,Alessandro Bertolino,Eugene Zaitsev,Bert Gold,David Goldman,Michael Dean,Bai Lu,Daniel R. Weinberger +12 more
TLDR
A role is demonstrated for BDNF and its val/met polymorphism in human memory and hippocampal function and it is suggested val/ met exerts these effects by impacting intracellular trafficking and activity-dependent secretion of BDNF.About:
This article is published in Cell.The article was published on 2003-01-24 and is currently open access. It has received 3599 citations till now. The article focuses on the topics: rs6265 & Hippocampal formation.read more
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A neurotrophic model for stress-related mood disorders.
TL;DR: Analysis of preclinical cellular and behavioral models of depression and antidepressant actions, as well as clinical neuroimaging and postmortem studies, are consistent with the hypothesis that decreased expression of BDNF and possibly other growth factors contributes to depression and that upregulation ofBDNF plays a role in the actions of antidepressant treatment.
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Be smart, exercise your heart: exercise effects on brain and cognition
TL;DR: A growing number of studies support the idea that physical exercise is a lifestyle factor that might lead to increased physical and mental health throughout life, at the molecular, cellular, systems and behavioural levels.
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The molecular neurobiology of depression
TL;DR: Recent studies combining behavioural, molecular and electrophysiological techniques reveal that certain aspects of depression result from maladaptive stress-induced neuroplastic changes in specific neural circuits and show that understanding the mechanisms of resilience to stress offers a crucial new dimension for the development of fundamentally novel antidepressant treatments.
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Molecular Genetics of Attention-Deficit/Hyperactivity Disorder
Stephen V. Faraone,Roy H. Perlis,Alysa E. Doyle,Jordan W. Smoller,Jennifer J. Goralnick,Meredith A. Holmgren,Pamela Sklar +6 more
TL;DR: Family, twin, and adoption studies provide compelling evidence that genes play a strong role in mediating susceptibility to ADHD, and seven genes for which the same variant has been studied in three or more case-control or family-based studies show statistically significant evidence of association with ADHD.
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Neurotrophins and their receptors: a convergence point for many signalling pathways.
TL;DR: Recent findings that neurotrophins, in addition to promoting survival and differentiation, exert various effects through surprising interactions with other receptors and ion channels are reviewed.
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Synaptic Activity and the Construction of Cortical Circuits
Lawrence C. Katz,Carla J. Shatz +1 more
TL;DR: The sequential combination of spontaneously generated and experience-dependent neural activity endows the brain with an ongoing ability to accommodate to dynamically changing inputs during development and throughout life.
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Effect of COMT Val108/158 Met genotype on frontal lobe function and risk for schizophrenia.
Michael F. Egan,Terry E. Goldberg,Bhaskar Kolachana,Joseph H. Callicott,C.M. Mazzanti,Richard E. Straub,David Goldman,Daniel R. Weinberger +7 more
TL;DR: The data suggest that the COMT Val allele, because it increases prefrontal dopamine catabolism, impairs prefrontal cognition and physiology, and by this mechanism slightly increases risk for schizophrenia.