G
Guido Poli
Researcher at Vita-Salute San Raffaele University
Publications - 259
Citations - 14819
Guido Poli is an academic researcher from Vita-Salute San Raffaele University. The author has contributed to research in topics: Virus & Viral replication. The author has an hindex of 62, co-authored 248 publications receiving 14196 citations. Previous affiliations of Guido Poli include Università telematica San Raffaele & University of Brescia.
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Journal ArticleDOI
Immunopathogenesis of human immunodeficiency virus infection
TL;DR: In this paper, the role of LFA-1 has been highlighted, and several factors in addition to endogenous viral regulatory proteins have been reported as capable of modulating the state of viral latency and expression in vitro.
Journal ArticleDOI
Towards an HIV cure: a global scientific strategy
Steven G. Deeks,Brigitte Autran,Ben Berkhout,Monsef Benkirane,Scott Cairns,Nicolas Chomont,Tae Wook Chun,Melissa J Churchill,Michele Di Mascio,Christine Katlama,Alain Lafeuillade,Alan L. Landay,Michael M. Lederman,Sharon R Lewin,Frank Maldarelli,David M. Margolis,Martin Markowitz,Javier Martinez-Picado,James I. Mullins,John W. Mellors,Santiago Moreno,Una O'Doherty,Sarah Palmer,Marie Capucine Penicaud,Matija Peterlin,Guido Poli,Jean-Pierre Routy,Christine Rouzioux,Guido Silvestri,Mario Stevenson,Amalio Telenti,Carine Van Lint,Eric Verdin,Anne Woolfrey,John A. Zaia,Françoise Barré-Sinoussi +35 more
TL;DR: The International AIDS Society convened a group of international experts to develop a scientific strategy for research towards an HIV cure and several priorities for basic, translational and clinical research were identified.
Journal Article
Monokine regulation of human immunodeficiency virus-1 expression in a chronically infected human T cell clone.
Kathleen A. Clouse,D Powell,I Washington,Guido Poli,K Strebel,W Farrar,P Barstad,J Kovacs,A S Fauci,T M Folks +9 more
TL;DR: A T cell clone (ACH-2) derived from T cells infected with HIV-2 was found to produce HIV-1 in response to stimulation with a monokine-enriched supernatant prepared by culturing human monocyte/macrophages with bacterial LPS (LPS-MO SN).
Journal ArticleDOI
Interleukin 6 induces human immunodeficiency virus expression in infected monocytic cells alone and in synergy with tumor necrosis factor alpha by transcriptional and post-transcriptional mechanisms.
Guido Poli,Peter Bressler,Audrey Kinter,Elia J. Duh,W C Timmer,Alan S. Rabson,Jesse S. Justement,Sharilyn K. Stanley,Anthony S. Fauci +8 more
TL;DR: The immunoregulatory cytokine interleukin 6 directly upregulates production of human immunodeficiency virus (HIV) in acutely as well as in chronically infected cells of monocytic lineage and synergizes with tumor necrosis factor alpha (TNF-alpha) in the induction of latent HIV expression.
Journal ArticleDOI
Tumor necrosis factor alpha functions in an autocrine manner in the induction of human immunodeficiency virus expression.
Guido Poli,Audrey Kinter,Jesse S. Justement,John H. Kehrl,Peter Bressler,Sharilyn K. Stanley,Anthony S. Fauci +6 more
TL;DR: This study illustrates the interrelationship between the regulation of HIV expression and normal immunoregulatory mechanisms in that virus expression can be modulated by an autocrine pathway involving TNF-alpha, a cytokine involved in the complex network of regulation of the normal human immune response.