A
Alexander Dietrich
Researcher at Ludwig Maximilian University of Munich
Publications - 132
Citations - 8613
Alexander Dietrich is an academic researcher from Ludwig Maximilian University of Munich. The author has contributed to research in topics: Transient receptor potential channel & TRPC. The author has an hindex of 49, co-authored 120 publications receiving 7689 citations. Previous affiliations of Alexander Dietrich include University of Ulm & University of Marburg.
Papers
More filters
Journal ArticleDOI
Activation of TRPC6 channels is essential for lung ischaemia–reperfusion induced oedema in mice
Norbert Weissmann,Akylbek Sydykov,Hermann Kalwa,Hermann Kalwa,Ursula Storch,Beate Fuchs,Michael Mederos y Schnitzler,Ralf P. Brandes,Friedrich Grimminger,Marcel Meissner,Marc Freichel,Stefan Offermanns,Florian Veit,Oleg Pak,Karl-Heinz Krause,Ralph T. Schermuly,Alison C. Brewer,Harald H.H.W. Schmidt,Werner Seeger,Ajay M. Shah,Thomas Gudermann,Hossein Ardeschir Ghofrani,Alexander Dietrich +22 more
TL;DR: A novel mechanistic model comprising endothelial Nox2-derived production of superoxide, activation of phospholipase C-γ, inhibition of diacylglycerol (DAG) kinase, DAG-mediated activation of TRPC6 and ensuing LIRE is supported by pharmacological and molecular evidence.
Journal ArticleDOI
Intestinal Dysbiosis, Barrier Dysfunction, and Bacterial Translocation Account for CKD–Related Systemic Inflammation
Kirstin Andersen,Marie Sophie Kesper,Julian A. Marschner,Lukas Konrad,Mi Ryu,Santhosh Kumar Vr,Onkar P. Kulkarni,Shrikant R. Mulay,Simone Romoli,Jana Demleitner,Patrick Schiller,Alexander Dietrich,Susanna Müller,Oliver Gross,Hans-Joachim Ruscheweyh,Daniel H. Huson,Bärbel Stecher,Hans-Joachim Anders +17 more
TL;DR: It is concluded that uremia associates with intestinal dysbiosis, intestinal barrier dysfunction, and bacterial translocation, which trigger the state of persistent systemic inflammation in CKD.
Journal ArticleDOI
TLR4 activation of TRPC6-dependent calcium signaling mediates endotoxin-induced lung vascular permeability and inflammation
Mohammad Tauseef,Nebojsa Nick Knezevic,Koteswara Rao Chava,Monica Smith,Sukriti Sukriti,Nicholas G. Gianaris,Alexander G. Obukhov,Stephen M. Vogel,Dean E. Schraufnagel,Alexander Dietrich,Lutz Birnbaumer,Asrar B. Malik,Dolly Mehta +12 more
TL;DR: In this paper, the role of TL-like receptor 4 intersection with TRPC6-dependent Ca2+ signaling in endothelial cells (ECs) in mediating lung vascular leakage and inflammation was investigated.
Journal ArticleDOI
The diacylgylcerol-sensitive TRPC3/6/7 subfamily of cation channels: functional characterization and physiological relevance
TL;DR: This review focuses on the TRPC3/6/7 subfamily and describes their functional properties and regulation as homomers obtained from overexpression studies in cell lines and presents initial data concerning their physiological functions analyzed in isolated tissues with downregulated channel activity and gene-deficient mouse models.
Journal ArticleDOI
Stimulation of phospholipase C-β2 by the Rho GTPases Cdc42Hs and Rac1
Daria Illenberger,Frieder Schwald,Dominik Pimmer,Wolfhard Binder,Gernot Maier,Alexander Dietrich,Peter Gierschik +6 more
TL;DR: PLCβ2 is identified as a novel effector of the Rho GTPases Cdc42Hs and Rac1, and as the first mammalian effector directly regulated by both heterotrimeric and low‐molecular‐mass GTP‐binding proteins.