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Alexander Leemans
Researcher at Utrecht University
Publications - 306
Citations - 21500
Alexander Leemans is an academic researcher from Utrecht University. The author has contributed to research in topics: Diffusion MRI & Fractional anisotropy. The author has an hindex of 64, co-authored 289 publications receiving 17932 citations. Previous affiliations of Alexander Leemans include Australian Catholic University & Cardiff University.
Papers
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Affine coregistration of diffusion tensor magnetic resonance images using mutual information
TL;DR: In this article, an affine image coregistration technique for Diffusion Tensor Magnetic Resonance Imaging (DT-MRI) data sets based on mutual information is presented, which is based on a multi-channel approach where the diffusion weighted images are aligned according to the corresponding acquisition gradient directions.
Book ChapterDOI
Checking and Correcting DTI Data
TL;DR: This chapter provides a practical overview of the most clinically relevant artifacts present in diffusion MRI data, and a step-by-step decision scheme provides advice on how to check and correct for artifacts.
Journal ArticleDOI
Mild cerebellar injury does not significantly affect cerebral white matter microstructural organization and neurodevelopmental outcome in a contemporary cohort of preterm infants
Richelle E M Senden,Kristin Keunen,Niek E. van der Aa,Alexander Leemans,Ivana Išgum,Max A. Viergever,Jeroen Dudink,Linda S. de Vries,Floris Groenendaal,Manon J.N.L. Benders +9 more
TL;DR: The findings suggest that the impact of mild CBH on early macroscale brain development may be limited, and future studies are needed to assess the effects ofCBH on long-term neurodevelopment.
Journal ArticleDOI
Microstructural white matter tissue characteristics are modulated by homocysteine: A diffusion tensor imaging study
Jung-Lung Hsu,Wei-Hung Chen,Chyi Huey Bai,Jyu-Gang Leu,Chien-Yeh Hsu,Max A. Viergever,Alexander Leemans +6 more
TL;DR: This is the first study demonstrating that DTI is sufficiently sensitive to relate microstructural WM properties to homocysteine levels in healthy subjects.
Journal ArticleDOI
Diffusion MRI harmonization enables joint-analysis of multicentre data of patients with cerebral small vessel disease
Bruno M. de Brito Robalo,Geert Jan Biessels,Christopher Chen,Anna Dewenter,Marco Duering,Marco Duering,Saima Hilal,Huiberdina L. Koek,Anna Kopczak,Bonnie Y.K. Lam,Alexander Leemans,Vincent Mok,Laurien P Onkenhout,Hilde van den Brink,Alberto De Luca +14 more
TL;DR: In this article, rotation invariant spherical harmonic (RISH) features were used to harmonize the raw diffusion signal in multicentre dMRI of elderly subjects with cerebral small vessel disease (SVD) while preserving sensitivity to disease effects.