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Alexander Leemans

Researcher at Utrecht University

Publications -  306
Citations -  21500

Alexander Leemans is an academic researcher from Utrecht University. The author has contributed to research in topics: Diffusion MRI & Fractional anisotropy. The author has an hindex of 64, co-authored 289 publications receiving 17932 citations. Previous affiliations of Alexander Leemans include Australian Catholic University & Cardiff University.

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A comparison of MR based segmentation methods for measuring brain atrophy progression.

TL;DR: US and kNN showed a good precision, accuracy and comparability for brain volume measurements and is a good alternative if volume change measurements of other brain structures are required.

Multiscale White Matter Fiber Tract Coregistration: A New Feature-Based Approach to Align Diffusion

TL;DR: In this paper, a multiscale feature-based rigid-body coregistration technique for diffusion tensor imaging (DTI) based on the local curvature and torsion of the white matter (WM) fiber pathways is presented.
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On the construction of a ground truth framework for evaluating voxel-based diffusion tensor MRI analysis methods

TL;DR: Simulated diffusion tensor data sets are developed, which can model an array of anomalies in the diffusion properties of a predefined location and can be employed to evaluate the numerous parameters that characterize the pipeline of a VBA algorithm and to compare the accuracy, precision, and reproducibility of different post-processing approaches quantitatively.
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Decoupling of structural and functional brain connectivity in older adults with white matter hyperintensities

TL;DR: Decoupling of connectivity, measured as the absolute difference between structural and functional connectivity, in the high WMH group was related to poorer executive functioning and memory performance, suggesting that such decoupling may reflect reorganization of functional networks in response to global white matter pathology.