A
Alexander Pichugin
Researcher at Walter Reed Army Institute of Research
Publications - 26
Citations - 662
Alexander Pichugin is an academic researcher from Walter Reed Army Institute of Research. The author has contributed to research in topics: Antigen & Immune system. The author has an hindex of 13, co-authored 26 publications receiving 577 citations. Previous affiliations of Alexander Pichugin include Harvard University & Russian Academy.
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Dominant role of the sst1 locus in pathogenesis of necrotizing lung granulomas during chronic tuberculosis infection and reactivation in genetically resistant hosts.
TL;DR: It is demonstrated that within the complex, multigenic architecture of tuberculosis susceptibility, sst1 functions to control necrosis within tuberculosis lesions in the lungs; this lung-specific sst 1 effect is independent of both the route of infection and genetic background of the host.
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Lung carcinogenesis induced by chronic tuberculosis infection: the experimental model and genetic control.
TL;DR: Experimental evidence that chronic TB infection induces cell dysplasia and squamous cell carcinoma in a lung-specific manner is presented and a genetic model for further analysis of carcinogenic mechanisms activated by TB infection is established.
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Comparative Analysis of T Lymphocytes Recovered from the Lungs of Mice Genetically Susceptible, Resistant, and Hyperresistant to Mycobacterium tuberculosis-Triggered Disease
Irina V. Lyadova,Evgenyi B. Eruslanov,S. V. Khaidukov,Vladimir Yeremeev,Konstantin B. Majorov,Alexander Pichugin,Boris Nikonenko,Tatiana Kondratieva,Alexander S. Apt +8 more
TL;DR: Parameters of lung T cell activation and response following M. tuberculosis challenge are compared to find a more balanced type of immune reactivity that could be linked to a better TB defense.
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An Unbiased Genome-Wide Mycobacterium tuberculosis Gene Expression Approach To Discover Antigens Targeted by Human T Cells Expressed during Pulmonary Infection
Susanna Commandeur,Krista E. van Meijgaarden,Corine Prins,Alexander Pichugin,Karin Dijkman,Susan J. F. van den Eeden,Annemieke H. Friggen,Kees L. M. C. Franken,Gregory Dolganov,Igor Kramnik,Gary K. Schoolnik,Fredrik Oftung,Gro Ellen Korsvold,Annemieke Geluk,Tom H. M. Ottenhoff +14 more
TL;DR: In conclusion, these IVE-TB Ags are expressed during pulmonary infection in vivo, are immunogenic, induce strong T cell responses in long-term latently M. tuberculosis–infected individuals, and may therefore represent attractive Ags for new TB vaccines.
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Progression of Pulmonary Tuberculosis and Efficiency of Bacillus Calmette-Guérin Vaccination Are Genetically Controlled via a Common sst1-Mediated Mechanism of Innate Immunity
Bo-Shiun Yan,Alexander Pichugin,Ousman Jobe,Laura Helming,Evgeniy Eruslanov,José A. Gutiérrez-Pabello,Mauricio Rojas,Yuriy V. Shebzukhov,Lester Kobzik,Igor Kramnik +9 more
TL;DR: The data suggest that in immunocompetent humans the development of pulmonary tuberculosis and the failure of the existing vaccine to protect against it, in some cases, may be explained by a similar defect in a conserved inducible NO synthase-independent mechanism of innate immunity, either inherited or acquired.