A
Alexandra C. Walls
Researcher at University of Washington
Publications - 96
Citations - 22743
Alexandra C. Walls is an academic researcher from University of Washington. The author has contributed to research in topics: Antibody & Biology. The author has an hindex of 32, co-authored 69 publications receiving 11885 citations. Previous affiliations of Alexandra C. Walls include University of Massachusetts Medical School.
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Journal ArticleDOI
Crucial steps in the structure determination of a coronavirus spike glycoprotein using cryo-electron microscopy
Alexandra C. Walls,M. Alejandra Tortorici,M. Alejandra Tortorici,Berend Jan Bosch,Brandon Frenz,Peter J. M. Rottier,Frank DiMaio,Félix A. Rey,Félix A. Rey,David Veesler +9 more
TL;DR: This work determined the first structure of a coronavirus S glycoprotein trimer which provided a framework to understand the mechanisms of viral entry and suggested potential inhibition strategies for this family of viruses.
Journal ArticleDOI
Safety and immunogenicity of a SARS-CoV-2 recombinant protein nanoparticle vaccine (GBP510) adjuvanted with AS03: A randomised, placebo-controlled, observer-blinded phase 1/2 trial
Joon Young Song,Won Suk Choi,Jung Yeon Heo,Jin Soo Lee,Dong Sik Jung,Shin Woo Kim,Kyung-Hwa Park,Joong Sik Eom,Su Jin Jeong,Jacob Lee,Ki Tae Kwon,Hee Jung Choi,Jang Wook Sohn,Young Keun Kim,Ji Yun Noh,Woo Joo Kim,François Roman,Maria Angeles Ceregido,Francesca Solmi,Agathe Philippot,Alexandra C. Walls,Lauren Carter,David Veesler,Neil P. King,Hun Kim,Ji Hwa Ryu,Su Jeen Lee,Yong-Wook Park,H. Park,Hee Jin Cheong +29 more
TL;DR: A randomized, placebo-controlled, observer-blinded phase 1/2 study was conducted to evaluate the safety and immunogenicity of GBP510 adjuvanted with or without AS03 in adults aged 19-85 years at 14 hospital sites in Korea as discussed by the authors .
Posted ContentDOI
Seroprevalence of SARS-CoV-2 among children visiting a hospital during the initial Seattle outbreak
Adam S. Dingens,Katharine H.D. Crawford,Katharine H.D. Crawford,Amanda Adler,Sarah L. Steele,Kirsten Lacombe,Rachel Eguia,Fatima Amanat,Alexandra C. Walls,Caitlin R Wolf,Michael E. P. Murphy,Deleah Pettie,Lauren Carter,Xuan Qin,Neil P. King,David Veesler,Florian Krammer,Jane A. Dickerson,Jane A. Dickerson,Helen Y. Chu,Janet A. Englund,Janet A. Englund,Jesse D. Bloom,Jesse D. Bloom,Jesse D. Bloom +24 more
TL;DR: Among children seeking medical care, the frequency of SARS-CoV-2 infection increased markedly during the early Seattle outbreak despite few positive viral tests.
Posted ContentDOI
SARS-CoV-2 B.1.1.7 escape from mRNA vaccine-elicited neutralizing antibodies
Ravindra K. Gupta,Dami A. Collier,Dami A. Collier,Anna De Marco,Isabella Ferreira,Bo Meng,Rawlings Datir,Rawlings Datir,Alexandra C. Walls,Steven Kemp,Jessica Bassi,Dora Pinto,Chiara Silacci-Fregni,Siro Bianchi,M. Alejandra Tortorici,John E. Bowen,Katja Culap,Stefano Jaconi,Elisabetta Cameroni,Gyorgy Snell,Matteo Samuele Pizzuto,Allessandra Pallanda,Christian Gorzoni,Agostino Riva,Anne Elmer,Barbara J. Graves,Laura E. McCoy,Kenneth G. C. Smith,John Bradley,James Thaventhiran,Lourdes Ceron-Gutierrez,Gabriela Barcenas-Morales,Herbert W. Virgin,Antonio Lanzavecchia,Luca Piccoli,Rainer Doffinger,Mark R. Wills,David Veesler,Davide Corti +38 more
TL;DR: Assessment of immune responses following vaccination with mRNA-based vaccine BNT162b2 measured neutralising antibody responses following a single immunization using pseudoviruses expressing the wild-type Spike protein or the 8 mutations found in the B.1.1-CoV-2 Spike protein.
Journal ArticleDOI
Stabilization of the SARS-CoV-2 Spike Receptor-Binding Domain Using Deep Mutational Scanning and Structure-Based Design.
Daniel Ellis,Natalie Brunette,Katharine H. D. Crawford,Katharine H. D. Crawford,Alexandra C. Walls,Minh N. Pham,Chengbo Chen,Karla-Luise Herpoldt,Brooke Fiala,Michael L. M. Murphy,Deleah Pettie,John C. Kraft,Keara D. Malone,Mary Jane Navarro,Cassandra Ogohara,Elizabeth Kepl,Rashmi Ravichandran,Claire Sydeman,Maggie Ahlrichs,Max Johnson,Alyssa Blackstone,Lauren Carter,Tyler N. Starr,Allison J. Greaney,Allison J. Greaney,Kelly K. Lee,David Veesler,Jesse D. Bloom,Jesse D. Bloom,Jesse D. Bloom,Neil P. King +30 more
TL;DR: In this article, the authors used previously reported deep mutational scanning (DMS) data to guide the design of stabilized variants of the receptor-binding domain (RBD) that have been identified as a linoleic acid binding pocket.