Alexandra Paye

TL;DR: In this article, a non-small cell lung carcinoma (NSCLC)-derived cell line (A549) was stably expressing miR-210 or a control miRNA (pmiR-Ctl).

TL;DR: Evidence for tumor adaptation to vascular endothelial growth factor blockade through a metabolic shift toward carbohydrate and lipid metabolism in tumors is provided and key molecules involved in lipid metabolism as putative therapeutic targets are identified.

TL;DR: Understanding of the nature of MT-MMP interaction with extracellular and cell surface molecules and their multiple roles in vessel walls and perivascular stroma may provide new insights into mechanisms underlying vascular cell–ECM interactions and cell fate decisions in pathological conditions.

TL;DR: It is proposed that MT4‐MMP promotes lung metastasis by disturbing the tumour vessel integrity and thereby facilitating tumour cell intravasation.

TL;DR: This report identifies MT4-MMP as a positive modifier of EGFR outside-in signaling that acts to cooperatively drive cancer cell proliferation through CDK4 activation and retinoblastoma protein inactivation.