Blocking Lipid Synthesis Overcomes Tumor Regrowth and Metastasis after Antiangiogenic Therapy Withdrawal
Nor Eddine Sounni,Jonathan Cimino,Silvia Blacher,Irina Primac,Alice Truong,Gabriel Mazzucchelli,Alexandra Paye,David Calligaris,Delphine Debois,Pascal De Tullio,Bernard Mari,Edwin De Pauw,Agnès Noël +12 more
TLDR
Evidence for tumor adaptation to vascular endothelial growth factor blockade through a metabolic shift toward carbohydrate and lipid metabolism in tumors is provided and key molecules involved in lipid metabolism as putative therapeutic targets are identified.About:
This article is published in Cell Metabolism.The article was published on 2014-08-05 and is currently open access. It has received 137 citations till now. The article focuses on the topics: Lipid metabolism & Sunitinib.read more
Citations
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Microenvironmental regulation of tumour angiogenesis
TL;DR: The extrinsic regulation of angiogenesis by the tumour microenvironment is discussed, highlighting potential vulnerabilities that could be targeted to improve the applicability and reach of anti-angiogenic cancer therapies.
Journal ArticleDOI
The multifaceted roles of fatty acid synthesis in cancer
Florian Röhrig,Almut Schulze +1 more
TL;DR: This Review explores how different aspects of FA synthesis promote tumorigenesis and tumour progression and strategies to target this pathway have not yet translated into clinical practice.
Journal ArticleDOI
Metabolic regulation of cell growth and proliferation.
Jiajun Zhu,Craig B. Thompson +1 more
TL;DR: A better understanding of how cells utilize nutrients for biosynthetic pathways and how they overcome the metabolic challenges associated with high proliferation rates can lead to better control of cell proliferation and improved cancer treatments.
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JAK/STAT3-Regulated Fatty Acid β-Oxidation Is Critical for Breast Cancer Stem Cell Self-Renewal and Chemoresistance.
Tianyi Wang,Tianyi Wang,Johannes F. Fahrmann,Heehyoung Lee,Yi Jia Li,Satyendra C. Tripathi,Chanyu Yue,Chunyan Zhang,Veronica Lifshitz,Jieun Song,Yuan Yuan,George Somlo,Rahul Jandial,David K. Ann,Samir M. Hanash,Richard Jove,Hua Yu +16 more
TL;DR: It is demonstrated that JAK/STAT3 regulates lipid metabolism, which promotes breast CSCs (BCSCs) and cancer chemoresistance, and human breast-cancer-derived data suggest that the STAT3-CPT1B-FAO pathway promotes cancer cell stemness and Chemoresistance.
Journal ArticleDOI
Emerging roles of lipid metabolism in cancer metastasis
Xiangjian Luo,Xiangjian Luo,Can Cheng,Can Cheng,Zheqiong Tan,Zheqiong Tan,Namei Li,Namei Li,Min Tang,Min Tang,Lifang Yang,Lifang Yang,Ya Cao,Ya Cao +13 more
TL;DR: The present review is focused on key enzymes in lipid metabolism associated with metastatic disease pathogenesis and the function of an important membrane structure-lipid raft in mediating tumor aggressive progression.
References
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HIF-1-mediated expression of pyruvate dehydrogenase kinase: A metabolic switch required for cellular adaptation to hypoxia
TL;DR: A hypoxia-induced metabolic switch that shunts glucose metabolites from the mitochondria to glycolysis to maintain ATP production and to prevent toxic ROS production is revealed.
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Antiangiogenic Therapy Elicits Malignant Progression of Tumors to Increased Local Invasion and Distant Metastasis
Marta Paez-Ribes,Elizabeth Allen,James Hudock,Takaaki Takeda,Hiroaki Okuyama,Francesc Viñals,Masahiro Inoue,Gabriele Bergers,Douglas Hanahan,Oriol Casanovas +9 more
TL;DR: It is reported that angiogenesis inhibitors targeting the VEGF pathway demonstrate antitumor effects in mouse models of pancreatic neuroendocrine carcinoma and glioblastoma but concomitantly elicit tumor adaptation and progression to stages of greater malignancy, with heightened invasiveness and in some cases increased lymphatic and distant metastasis.
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Accelerated Metastasis after Short-Term Treatment with a Potent Inhibitor of Tumor Angiogenesis
John M.L. Ebos,Christina R. Lee,William Cruz-Munoz,Georg A. Bjarnason,James G. Christensen,Robert S. Kerbel,Robert S. Kerbel +6 more
TL;DR: It is reported that the VEGFR/PDGFR kinase inhibitor sunitinib/SU11248 can accelerate metastatic tumor growth and decrease overall survival in mice receiving short-term therapy in various metastasis assays, including after intravenous injection of tumor cells or after removal of primary orthotopically grown tumors.
Journal ArticleDOI
Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice
Pierre Sonveaux,Frédérique Végran,Thies Schroeder,Melanie Wergin,Julien Verrax,Zahid N. Rabbani,Christophe De Saedeleer,Kelly M. Kennedy,Caroline Diepart,Bénédicte F. Jordan,Michael J. Kelley,Bernard Gallez,Miriam L. Wahl,Olivier Feron,Mark W. Dewhirst +14 more
TL;DR: In this paper, the authors identified monocarboxylate transporter 1 (MCT1) as the prominent path for lactate uptake by a human cervix squamous carcinoma cell line that preferentially utilized lactate for oxidative metabolism.
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Cellular fatty acid metabolism and cancer
TL;DR: Evidence that limiting fatty acid availability can control cancer cell proliferation is summarized, and a view of cancer cell metabolism from a lipid perspective is provided.