A
Alexandre Puissant
Researcher at French Institute of Health and Medical Research
Publications - 81
Citations - 4197
Alexandre Puissant is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: Myeloid leukemia & Leukemia. The author has an hindex of 33, co-authored 68 publications receiving 3631 citations. Previous affiliations of Alexandre Puissant include Boston Children's Hospital & Paris Diderot University.
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Journal ArticleDOI
Targeting MYCN in Neuroblastoma by BET Bromodomain Inhibition
Alexandre Puissant,Stacey M. Frumm,Gabriela Alexe,Christopher F. Bassil,Jun Qi,Yvan Chanthery,Erin A. Nekritz,Rhamy Zeid,William Clay Gustafson,Patricia Greninger,Matthew J. Garnett,Ultan McDermott,Cyril H. Benes,Andrew L. Kung,William A. Weiss,James E. Bradner,Kimberly Stegmaier +16 more
TL;DR: A cell-based screen of genetically defined cancer cell lines using a prototypical inhibitor of BET bromodomains revealed a robust correlation between MYCN amplification and sensitivity to bromidomain inhibition, and characterized the mechanistic and translational significance of this finding in neuroblastoma.
Journal ArticleDOI
Resveratrol Promotes Autophagic Cell Death in Chronic Myelogenous Leukemia Cells via JNK-Mediated p62/SQSTM1 Expression and AMPK Activation
Alexandre Puissant,Guillaume Robert,Nina Fenouille,Frederic Luciano,Cassuto Jp,Sophie Raynaud,Patrick Auberger +6 more
TL;DR: It is concluded that RSV triggered autophagic cell death in CML cells via both JNK-mediated p62 overexpression and AM PK activation, and the findings show that the JNK and AMPK pathways can cooperate to eliminate C ML cells via autophagy.
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Metformin inhibits melanoma development through autophagy and apoptosis mechanisms
Tomic T,Thomas Botton,Thomas Botton,Michael Cerezo,Michael Cerezo,Guillaume Robert,Guillaume Robert,Frederic Luciano,Frederic Luciano,Alexandre Puissant,Alexandre Puissant,Pierre Gounon,Maryline Allegra,Maryline Allegra,Corine Bertolotto,Corine Bertolotto,Bereder Jm,Sophie Tartare-Deckert,Sophie Tartare-Deckert,Philippe Bahadoran,Philippe Bahadoran,Patrick Auberger,Patrick Auberger,Robert Ballotti,Robert Ballotti,Stéphane Rocchi,Stéphane Rocchi +26 more
TL;DR: The data suggest that metformin has an important impact on melanoma growth, and may therefore be beneficial in patients with melanoma.
Journal Article
When autophagy meets cancer through p62/SQSTM1
TL;DR: Because p62 is an autophagic substrate, it acts as a molecular link between cancer and autophagy by conferring a high level of selectivity through the degradation of important signaling molecules.
Journal ArticleDOI
In Vivo RNAi Screening Identifies a Leukemia-Specific Dependence on Integrin Beta 3 Signaling
Peter Miller,Fatima Al-Shahrour,Fatima Al-Shahrour,Kimberly A. Hartwell,Lisa P. Chu,Marcus Järås,Rishi V. Puram,Alexandre Puissant,Kevin P. Callahan,John M. Ashton,Marie McConkey,Luke Poveromo,Glenn S. Cowley,Michael G. Kharas,Myriam Labelle,Sebastian Shterental,Joji Fujisaki,Lev Silberstein,Gabriela Alexe,Muhammad Al-Hajj,Christopher A. Shelton,Scott A. Armstrong,David E. Root,David T. Scadden,Richard O. Hynes,Richard O. Hynes,Siddhartha Mukherjee,Kimberly Stegmaier,Kimberly Stegmaier,Craig T. Jordan,Benjamin L. Ebert,Benjamin L. Ebert +31 more
TL;DR: It is found that Integrin Beta 3 (Itgb3) is essential for murine leukemia cells in vivo and for human leukemia Cells in xenotransplantation studies and confirmed that Itgb3 is dispensable for normal hematopoiesis but is required for leukemogenesis.