D
David E. Root
Researcher at Harvard University
Publications - 25
Citations - 1580
David E. Root is an academic researcher from Harvard University. The author has contributed to research in topics: Cancer & Reporter gene. The author has an hindex of 12, co-authored 25 publications receiving 1487 citations. Previous affiliations of David E. Root include Massachusetts Institute of Technology & Broad Institute.
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Journal ArticleDOI
AKT-Independent Signaling Downstream of Oncogenic PIK3CA Mutations in Human Cancer
Krishna Murthi Vasudevan,David A. Barbie,David A. Barbie,Michael A. Davies,Rosalia Rabinovsky,Chontelle J. McNear,Jessica J. Kim,Bryan T. Hennessy,Hsiuyi Tseng,Panisa Pochanard,So Young Kim,So Young Kim,Ian F. Dunn,Anna C. Schinzel,Anna C. Schinzel,Peter Sandy,Sebastian Hoersch,Qing Sheng,Piyush Gupta,Jesse S. Boehm,Jan H. Reiling,Serena J. Silver,Yiling Lu,Katherine Stemke-Hale,Bhaskar Dutta,Corwin Joy,Aysegul A. Sahin,Ana M. Gonzalez-Angulo,Ana Lluch,Lucia E. Rameh,Tyler Jacks,David E. Root,Eric S. Lander,Gordon B. Mills,William C. Hahn,William R. Sellers,William R. Sellers,Levi A. Garraway +37 more
TL;DR: This paper showed that SGK3 undergoes PI3K-and PDK1-dependent activation in PIK3CA mutant cancer cells and showed that these cells retain robust PDK 1 activation and membrane localization and exhibit dependency on the SGK 1 substrate SGK 3.
AKT-Independent Signaling Downstream of Oncogenic PIK3CA Mutations in Human Cancer
Krishna Murthi Vasudevan,David A. Barbie,David A. Barbie,Michael A. Davies,Rosalia Rabinovsky,Chontelle J. McNear,Jessica J. Kim,Bryan T. Hennessy,Hsiuyi Tseng,Panisa Pochanard,So Young Kim,So Young Kim,Ian F. Dunn,Anna C. Schinzel,Anna C. Schinzel,Peter Sandy,Sebastian Hoersch,Qing Sheng,Piyush Gupta,Jesse S. Boehm,Jan H. Reiling,Serena J. Silver,Yiling Lu,Katherine Stemke-Hale,Bhaskar Dutta,Corwin Joy,Aysegul A. Sahin,Ana M. Gonzalez-Angulo,Ana Lluch,Lucia E. Rameh,Tyler Jacks,David E. Root,Eric S. Lander,Gordon B. Mills,William C. Hahn,William R. Sellers,William R. Sellers,Levi A. Garraway +37 more
TL;DR: It is shown through phosphoprotein profiling and functional genomic studies that many PIK3CA mutant cancer cell lines and human breast tumors exhibit only minimal AKT activation and a diminished reliance on AKT for anchorage-independent growth.
Journal ArticleDOI
In Vivo RNAi Screening Identifies a Leukemia-Specific Dependence on Integrin Beta 3 Signaling
Peter Miller,Fatima Al-Shahrour,Fatima Al-Shahrour,Kimberly A. Hartwell,Lisa P. Chu,Marcus Järås,Rishi V. Puram,Alexandre Puissant,Kevin P. Callahan,John M. Ashton,Marie McConkey,Luke Poveromo,Glenn S. Cowley,Michael G. Kharas,Myriam Labelle,Sebastian Shterental,Joji Fujisaki,Lev Silberstein,Gabriela Alexe,Muhammad Al-Hajj,Christopher A. Shelton,Scott A. Armstrong,David E. Root,David T. Scadden,Richard O. Hynes,Richard O. Hynes,Siddhartha Mukherjee,Kimberly Stegmaier,Kimberly Stegmaier,Craig T. Jordan,Benjamin L. Ebert,Benjamin L. Ebert +31 more
TL;DR: It is found that Integrin Beta 3 (Itgb3) is essential for murine leukemia cells in vivo and for human leukemia Cells in xenotransplantation studies and confirmed that Itgb3 is dispensable for normal hematopoiesis but is required for leukemogenesis.
Brief Communication Indoprofen Upregulates the Survival Motor Neuron Protein through a Cyclooxygenase-Independent Mechanism
Mitchell R. Lunn,David E. Root,Allison M. Martino,Stephen P. Flaherty,Brian P. Kelley,Daniel D. Coovert,Arthur H.M. Burghes,Glenn E. Morris,Jianhua Zhou,Elliot J. Androphy,Charlotte J. Sumner,Brent R. Stockwell,Amsterdam Avenue +12 more
TL;DR: In this paper, the authors tested 20,000 compounds from a combinatorial SMN2 gene to increase the production of an SMN-luciferase re-porter.
Journal ArticleDOI
Towards patient-based cancer therapeutics
Stuart L. Schreiber,Alykhan F. Shamji,Paul A. Clemons,Cindy S. Hon,Angela N. Koehler,Benito Munoz,Michelle Palmer,Andrew M. Stern,Bridget K. Wagner,Scott Powers,Scott W. Lowe,Xuecui Guo,Alexander Krasnitz,Eric T. Sawey,Raffaella Sordella,Lincoln Stein,Lloyd C. Trotman,Andrea Califano,Riccardo Dalla-Favera,Adolfo A. Ferrando,Antonio Iavarone,Laura Pasqualucci,Jose M. Silva,Brent R. Stockwell,William C. Hahn,Lynda Chin,Ronald A. DePinho,Jesse S. Boehm,Shuba Gopal,Alan Huang,David E. Root,Barbara A. Weir,Daniela S. Gerhard,Jean C. Zenklusen,Michael G. Roth,Michael A. White,John D. Minna,John B. MacMillan,Bruce A. Posner +38 more
TL;DR: A new approach to the discovery of cancer therapeutics is emerging that begins with the cancer patient, relating the genetic features of cancers to acquired gene and pathway dependencies and identifying small-molecule therapeutics that target them.