G
Gabriela Alexe
Researcher at Harvard University
Publications - 138
Citations - 6917
Gabriela Alexe is an academic researcher from Harvard University. The author has contributed to research in topics: Myeloid leukemia & Cancer. The author has an hindex of 39, co-authored 125 publications receiving 5808 citations. Previous affiliations of Gabriela Alexe include Broad Institute & University of California, San Francisco.
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Journal ArticleDOI
Carcinoma-Associated Fibroblast–Like Differentiation of Human Mesenchymal Stem Cells
Pravin J. Mishra,Prasun J. Mishra,Rita Humeniuk,Daniel J. Medina,Gabriela Alexe,Jill P. Mesirov,Sridhar Ganesan,John Glod,Debabrata Banerjee +8 more
TL;DR: It is shown that human bone marrow-derived mesenchymal stem cells exposed to tumor-conditioned medium (TCM) over a prolonged period of time assume a CAF-like myofibroblastic phenotype, which suggests that hMSCs are a source of CAFs and can be used in the modeling of tumor-stroma interactions.
Journal ArticleDOI
Targeting MYCN in Neuroblastoma by BET Bromodomain Inhibition
Alexandre Puissant,Stacey M. Frumm,Gabriela Alexe,Christopher F. Bassil,Jun Qi,Yvan Chanthery,Erin A. Nekritz,Rhamy Zeid,William Clay Gustafson,Patricia Greninger,Matthew J. Garnett,Ultan McDermott,Cyril H. Benes,Andrew L. Kung,William A. Weiss,James E. Bradner,Kimberly Stegmaier +16 more
TL;DR: A cell-based screen of genetically defined cancer cell lines using a prototypical inhibitor of BET bromodomains revealed a robust correlation between MYCN amplification and sensitivity to bromidomain inhibition, and characterized the mechanistic and translational significance of this finding in neuroblastoma.
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The genomic landscape of pediatric Ewing sarcoma
Brian D. Crompton,Chip Stewart,Amaro Taylor-Weiner,Gabriela Alexe,Kyle C. Kurek,Monica L. Calicchio,Adam Kiezun,Scott L. Carter,Sachet A. Shukla,Swapnil Mehta,Aaron R. Thorner,Carmen de Torres,Cinzia Lavarino,Mariona Suñol,Aaron McKenna,Andrey Sivachenko,Kristian Cibulskis,Michael S. Lawrence,Petar Stojanov,Mara Rosenberg,Lauren Ambrogio,Daniel Auclair,Sara Seepo,Brendan Blumenstiel,Matthew Defelice,Ivan Imaz-Rosshandler,Angela Schwarz-Cruz y Celis,Miguel Rivera,Carlos Rodriguez-Galindo,Mark D. Fleming,Todd R. Golub,Gad Getz,Jaume Mora,Kimberly Stegmaier,Kimberly Stegmaier +34 more
TL;DR: Next-generation sequencing of Ewing sarcoma found remarkably few mutations, however, it was discovered that loss of STAG2 expression occurs in 15% of tumors and is associated with metastatic disease, suggesting a potential genetic vulnerability in Ewing Sarcoma.
Journal ArticleDOI
Origin and differentiation of human memory CD8 T cells after vaccination
Rama Akondy,Mark Fitch,Srilatha Edupuganti,Shu Yang,Haydn T. Kissick,Kelvin Li,Ben Youngblood,Ben Youngblood,Hossam A. Abdelsamed,Donald J. McGuire,Kristen W. Cohen,Gabriela Alexe,Gabriela Alexe,Shashi Nagar,Megan McCausland,Satish Gupta,Pramila Tata,W. Nicholas Haining,W. Nicholas Haining,M. Juliana McElrath,David W. Zhang,Bin Hu,William J. Greenleaf,Jörg J. Goronzy,Mark J. Mulligan,Marc K. Hellerstein,Rafi Ahmed +26 more
TL;DR: Open chromatin profile at effector genes was maintained in memory CD8 T cells isolated even a decade after vaccination, indicating that these cells retain an epigenetic fingerprint of their effector history and remain poised to respond rapidly upon re-exposure to the pathogen.
Journal ArticleDOI
Identifying mRNA targets of microRNA dysregulated in cancer: with application to clear cell Renal Cell Carcinoma
Huiqing Liu,A. R. Brannon,Anupama Reddy,Gabriela Alexe,Michael Seiler,Alexandra Arreola,Jay Oza,Ming Yao,David Juan,Louis S. Liou,Louis S. Liou,Shridar Ganesan,Arnold J. Levine,W.K. Rathmell,Gyan Bhanot +14 more
TL;DR: A simple and reliable method to identify direct gene targets of microRNA dysregulated in cancers from expression level measurements in patient matched tumor/normal samples and revealed many new regulations in ccRCC.