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Alexey V. Terskikh
Researcher at Discovery Institute
Publications - 86
Citations - 6529
Alexey V. Terskikh is an academic researcher from Discovery Institute. The author has contributed to research in topics: Stem cell & Embryonic stem cell. The author has an hindex of 37, co-authored 80 publications receiving 5966 citations. Previous affiliations of Alexey V. Terskikh include École Polytechnique Fédérale de Lausanne & Sanford-Burnham Institute for Medical Research.
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Journal ArticleDOI
Genetically encoded fluorescent indicator for intracellular hydrogen peroxide
Vsevolod V. Belousov,Arkady F. Fradkov,Konstantin A. Lukyanov,Dmitry B. Staroverov,Konstantin S Shakhbazov,Alexey V. Terskikh,Alexey V. Terskikh,Sergey Lukyanov +7 more
TL;DR: A genetically encoded, highly specific fluorescent probe for detecting hydrogen peroxide (H2O2) inside living cells, named HyPer, consists of circularly permuted yellow fluorescent protein (cpYFP) inserted into the regulatory domain of the prokaryotic H 2O2-sensing protein, OxyR.
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"Fluorescent timer": protein that changes color with time.
Alexey V. Terskikh,Arkady F. Fradkov,Galina V. Ermakova,Andrey G. Zaraisky,Patrick Tan,Andrey V. Kajava,Xiaoning Zhao,Sergey Lukyanov,Mikhail V. Matz,Stuart K. Kim,Irving L. Weissman,Paul D. Siebert +11 more
TL;DR: In vivo labeling with E5 is used to measure expression from the heat shock-dependent promoter in Caenorhabditis elegans and from the Otx-2 promoter in developing Xenopus embryos to monitor both activation and down-regulation of target promoters on the whole-organism scale.
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From hematopoiesis to neuropoiesis: Evidence of overlapping genetic programs
Alexey V. Terskikh,Mathew C. Easterday,Linheng Li,Leroy Hood,Harley I. Kornblum,Daniel H. Geschwind,Irving L. Weissman +6 more
TL;DR: It is proposed that at least some of the transcripts that are selectively and commonly expressed in two or more types of stem cells define a functionally conserved group of genes evolved to participate in basic stem cell functions, including stem cell self-renewal.
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Bcl-2 and Bcl-XL regulate proinflammatory caspase-1 activation by interaction with NALP1.
Jean-Marie Bruey,Nathalie Bruey-Sedano,Frederic Luciano,Dayong Zhai,Ruchi Balpai,Chunyan Xu,Christina L. Kress,Béatrice Bailly-Maitre,Xiaoqing Li,Andrei L. Osterman,Shu-ichi Matsuzawa,Alexey V. Terskikh,Benjamin Faustin,John C. Reed +13 more
TL;DR: The findings reveal an interaction of host defense and apoptosis machinery in the NLR-family protein NALP1, a nucleotide-dependent activator of cytokine-processing protease caspase-1, which responds to bacterial ligand muramyl-dipeptide.
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GFP‐like chromoproteins as a source of far‐red fluorescent proteins
Nadya G. Gurskaya,Arkady F. Fradkov,Alexey V. Terskikh,Mikhail V. Matz,Yulii Aleksandrovich Labas,Vladimir I. Martynov,Yurii G. Yanushevich,Konstantin A. Lukyanov,Sergey Lukyanov +8 more
TL;DR: In this article, an identical single amino acid substitution converted novel chromoproteins from the species Anthozoa (Heteractis crispa, Condylactis gigantea, and Goniopora tenuidens) into far-red fluorescent proteins (FPs) (emission lambda(max)=615-640 nm).