John Guy

TL;DR: Although the differences between the groups decreased with time, at six months the group that received intravenous methylprednisolone still had slightly better visual fields, contrast sensitivity, and color vision but not better visual acuity.

TL;DR: Gfph, a synthetic version of the jellyfish Aequorea victoria green fluorescent protein cDNA that is adapted for high-level expression in mammalian cells, can be readily sorted by fluorescence-activated cell sorting, suggesting that the newly designed gfph gene could be widely used as a reporter in many gene delivery technologies, including human gene therapy.

TL;DR: Results from the Ischemic Optic Neuropathy Decompression Trial indicate that optic nerve decompression surgery for NAION is not effective, may be harmful, and should be abandoned.

TL;DR: Allotopic expression of stably transfected constructs in cytoplasmic hybrids (cybrids) homoplasmic with respect to the 8993T→G mutation showed a significantly improved recovery after growth in selective medium as well as a significant increase in ATP synthesis.

TL;DR: Restoration of respiration by allotopic expression opens the door for gene therapy of Leber Hereditary Optic Neuropathy by correcting a defect in the mitochondrial genome linked to a human disease.