Ali I Rae

TL;DR: This study shows that clinical response to anti-PD-1 immunotherapy in GBM is associated with specific molecular alterations, immune expression signatures, and immune infiltration that reflect the tumor’s clonal evolution during treatment.

TL;DR: GTR + RT may be optimal in the management CNS HPC and SFT/HPC tumors with borderline/malignant features and warrants further investigation of adjuvant radiation through a prospective clinical trial.

TL;DR: Craniotomy is associated with increased survival over biopsy for PCNSL in 3 retrospective datasets and future studies should evaluate patients most likely to benefit from cytoreductive surgery, ie, those with favorable RPA and RC.

TL;DR: Findings in this U.S. population-based cohort support national guidelines and suggest greater EOR is associated with improved survival in oligodendrogliomas.

TL;DR: By using the National Cancer Database, the authors have demonstrated a side-by-side comparison of the survival benefits of greater EOR in 1p/19q-codeleted gliomas, and found that tumors by each classification system for predictors of overall survival, facility setting, age, comorbidity index, grade, location, chemotherapy, and radiation therapy were all shown to be significantly associated with overall survival.