Luis Aparicio

TL;DR: This study shows that clinical response to anti-PD-1 immunotherapy in GBM is associated with specific molecular alterations, immune expression signatures, and immune infiltration that reflect the tumor’s clonal evolution during treatment.

TL;DR: This Roadmap differentiates Mathematical Oncology from related fields and demonstrates specific areas of focus within this unique field of research, with the dominant theme of the personalization of medicine through mathematics, modelling, and simulation.

TL;DR: A comprehensive single-cell atlas of the adult mouse prostate epithelium is described, which displays extensive heterogeneity and elucidate new prostate epithelial progenitors, and help resolve long-standing questions about anatomical relationships between the mouse and human prostate.

TL;DR: This work proposes a new method based on random matrix theory to analyze and denoise single-cell sequencing data, and explains how sparsity can cause spurious eigenvector localization, falsely identifying meaningful directions in the data.