A
Ali Salanti
Researcher at Copenhagen University Hospital
Publications - 153
Citations - 7315
Ali Salanti is an academic researcher from Copenhagen University Hospital. The author has contributed to research in topics: Plasmodium falciparum & Antibody. The author has an hindex of 43, co-authored 140 publications receiving 6283 citations. Previous affiliations of Ali Salanti include University of Copenhagen & Panum Institute.
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Journal ArticleDOI
Selective upregulation of a single distinctly structured var gene in chondroitin sulphate A-adhering Plasmodium falciparum involved in pregnancy-associated malaria
Ali Salanti,Trine Staalsoe,Thomas Lavstsen,Anja T. R. Jensen,M. P. Kordai Sowa,David E. Arnot,Lars Hviid,Thor G. Theander +7 more
TL;DR: Mark upregulation of a single var gene in several P. falciparum parasite isolates after selection for adhesion to CSA in vitro has the properties expected of a gene encoding the parasite adhesion molecule that initiates the pathology associated with PAM.
Journal ArticleDOI
Evidence for the involvement of VAR2CSA in pregnancy-associated malaria.
Ali Salanti,Madeleine Dahlbäck,Madeleine Dahlbäck,Louise Turner,Louise Turner,Morten Nielsen,Morten Nielsen,Lea Barfod,Lea Barfod,Pamela Magistrado,Pamela Magistrado,Anja T. R. Jensen,Anja T. R. Jensen,Thomas Lavstsen,Thomas Lavstsen,Michael F. Ofori,Michael F. Ofori,Kevin Marsh,Lars Hviid,Lars Hviid,Thor G. Theander,Thor G. Theander +21 more
TL;DR: It is shown that VAR2CSA is expressed on the surface of CSA-selected IEs, which means that women with high plasma levels of anti-VAR1CSA IgG give birth to markedly heavier babies and have a much lower risk of delivering low birth weight children than women with low levels.
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Sub-grouping of Plasmodium falciparum 3D7 var genes based on sequence analysis of coding and non-coding regions.
TL;DR: The grouping of var genes implies that var gene recombination preferentially occurs within var gene groups and it is speculated that the groups reflect a functional diversification evolved to cope with the varying conditions of transmission and host immune response met by the parasite.
Journal ArticleDOI
Plasmodium falciparum associated with severe childhood malaria preferentially expresses PfEMP1 encoded by group A var genes.
Anja T. R. Jensen,Pamela Magistrado,Sarah Sharp,Louise Joergensen,Thomas Lavstsen,Antonella Chiucchiuini,Ali Salanti,Lasse S Vestergaard,John Lusingu,Rob Hermsen,Robert W. Sauerwein,Jesper Christensen,Morten Nielsen,Lars Hviid,Colin J. Sutherland,Trine Staalsoe,Thor G. Theander +16 more
TL;DR: The proteins encoded by Group A var genes, such as PFD1235w/MAL7P1.1, appear to be involved in the pathogenesis of severe disease and are thus attractive candidates for a vaccine against life-threatening P. falciparum malaria.
Journal ArticleDOI
High Level of var2csa Transcription by Plasmodium falciparum Isolated from the Placenta
Nicaise Tuikue Ndam,Ali Salanti,Gwladys Bertin,Madeleine Dahlbäck,Nadine Fievet,Louise Turner,Alioune Gaye,Thor G. Theander,Philippe Deloron +8 more
TL;DR: It is shown that placental P. falciparum isolates highly transcribed var2csa but not var1csa, which supports the idea that VAR2CSA plays a crucial role in PAM and strengthens the rationale for the development of VAR 2CSA-based vaccines.