J
John Lusingu
Researcher at National Institute for Medical Research
Publications - 140
Citations - 8518
John Lusingu is an academic researcher from National Institute for Medical Research. The author has contributed to research in topics: Malaria & Plasmodium falciparum. The author has an hindex of 42, co-authored 126 publications receiving 7235 citations. Previous affiliations of John Lusingu include Health Science University & Copenhagen University Hospital.
Papers
More filters
Journal ArticleDOI
First results of phase 3 trial of RTS,S/AS01 malaria vaccine in African children.
Selidji T Agnandji,Bertrand Lell,Bertrand Lell,Solange Soulanoudjingar,Solange Soulanoudjingar,José Francisco Fernandes,José Francisco Fernandes,Béatrice Peggy Abossolo,Béatrice Peggy Abossolo,Cornelia Conzelmann,Cornelia Conzelmann,Barbara Gaelle Nfono Ondo Methogo,Barbara Gaelle Nfono Ondo Methogo,Yannick Doucka,Yannick Doucka,Arnaud Flamen,Arnaud Flamen,Benjamin Mordmüller,Benjamin Mordmüller,Saadou Issifou,Saadou Issifou,Peter G. Kremsner,Peter G. Kremsner,Jahit Sacarlal,Pedro Aide,Miguel A. Lanaspa,John J. Aponte,Arlindo Nhamuave,Diana Quelhas,Quique Bassat,Sofia Mandjate,Eusebio Macete,Pedro L. Alonso,Salim Abdulla,Nahya Salim,Omar Juma,Mwanajaa Shomari,Kafuruki Shubis,Francisca Machera,Ali Hamad,Rose Minja,Ali Mtoro,Alma Sykes,Saumu Ahmed,Alwisa Urassa,Ali Ali,Grace Mwangoka,Marcel Tanner,Halidou Tinto,Umberto D'Alessandro,Hermann Sorgho,Innocent Valea,Marc Christian Tahita,William Kabore,Sayouba Ouedraogo,Yara Sandrine,Robert T. Guiguemdé,Jean-Bosco Ouédraogo,Mary J. Hamel,Simon Kariuki,Chris Odero,Martina Oneko,Kephas Otieno,Norbert Awino,Jackton Omoto,John Williamson,Vincent Muturi-Kioi,Kayla F. Laserson,Laurence Slutsker,Walter Otieno,Lucas Otieno,Otsyula Nekoye,Stacey M. O. Gondi,Allan Otieno,Bernhards Ogutu,Ruth Wasuna,Victorine Owira,David B. Jones,Agnes Akoth Onyango,Patricia Njuguna,Roma Chilengi,Pauline Akoo,Christine Kerubo,Jesse Gitaka,Charity Maingi,Trudie Lang,Ally Olotu,Benjamin Tsofa,Philip Bejon,Norbert Peshu,Kevin Marsh,Seth Owusu-Agyei,Kwaku Poku Asante,Kingsley Osei-Kwakye,Owusu Boahen,Samuel Ayamba,Kingsley Kayan,Ruth Owusu-Ofori,David Dosoo,Isaac Asante,George Adjei,Daniel Chandramohan,Brian Greenwood,John Lusingu,Samwel Gesase,Anangisye Malabeja,Omari Abdul,Hassan Kilavo,Coline Mahende,Edwin Liheluka,Martha M. Lemnge,Thor G. Theander,Chris Drakeley,Daniel Ansong,Tsiri Agbenyega,Samuel Adjei,Harry Owusu Boateng,Theresa Rettig,John Bawa,Justice Sylverken,David Sambian,Alex Agyekum,Larko Owusu,Francis Martinson,Irving F. Hoffman,Tisungane Mvalo,Portia Kamthunzi,Ruthendo Nkomo,Albans Msika,Allan Jumbe,Nelecy Chome,Dalitso Nyakuipa,Joseph Chintedza,W. Ripley Ballou,Myriam Bruls,Joe Cohen,Yolanda Guerra,Erik Jongert,Didier Lapierre,Amanda J. Leach,Marc Lievens,Opokua Ofori-Anyinam,Johan Vekemans,Terrell Carter,Didier Leboulleux,Christian Loucq,Afiya Radford,Barbara Savarese,David Schellenberg,Marla Sillman,Preeti Vansadia +150 more
TL;DR: The RTS,S/AS01 vaccine provided protection against both clinical and severe malaria in African children, and serious adverse events occurred with a similar frequency in the two study groups.
Journal ArticleDOI
National and regional estimates of term and preterm babies born small for gestational age in 138 low-income and middle-income countries in 2010
Anne C C Lee,Anne C C Lee,Joanne Katz,Hannah Blencowe,Simon Cousens,Naoko Kozuki,Joshua P. Vogel,Joshua P. Vogel,Linda S. Adair,Abdullah H Baqui,Zulfiqar A Bhutta,Laura E. Caulfield,Parul Christian,Siân E. Clarke,Majid Ezzati,Wafaie W. Fawzi,Rogelio Gonzalez,Lieven Huybregts,Lieven Huybregts,Simon Kariuki,Patrick Kolsteren,Patrick Kolsteren,John Lusingu,Tanya Marchant,Mario Merialdi,Aroonsri Mongkolchati,Luke C. Mullany,James Ndirangu,Marie-Louise Newell,Marie-Louise Newell,Jyh Kae Nien,David Osrin,Dominique Roberfroid,Heather E. Rosen,Ayesha Sania,Mariangela F. Silveira,James M. Tielsch,Anjana Vaidya,Barbara Willey,Joy E Lawn,Joy E Lawn,Robert E. Black +41 more
TL;DR: The burden of small-for-gestational-age births is very high in countries of low and middle income and is concentrated in south Asia.
Journal ArticleDOI
Estimating medium- and long-term trends in malaria transmission by using serological markers of malaria exposure
Chris Drakeley,Patrick H. Corran,Paul G. Coleman,Jon Eric Tongren,Suzanna L. R. McDonald,Ilona Carneiro,Robert Malima,John Lusingu,Alphaxard Manjurano,Watoky M. M. M. Nkya,M.M. Lemnge,Jonathan Cox,Hugh Reyburn,Eleanor M. Riley +13 more
TL;DR: This work compared the prevalence of IgG antibodies with three Plasmodium falciparum asexual stage antigens in individuals of all ages living at varying altitudes encompassing a range of transmission intensities from hyper- to hypoendemic in northeastern Tanzania, with alternative measures of transmission intensity.
Journal ArticleDOI
Severe malaria is associated with parasite binding to endothelial protein C receptor
Louise Turner,Thomas Lavstsen,Sanne S. Berger,Christian W. Wang,Jens E.V. Petersen,Marion Avril,Andrew J. Brazier,Jim Freeth,Jakob S. Jespersen,Morten Nielsen,Pamela Magistrado,John Lusingu,Joseph D. Smith,Joseph D. Smith,Matthew K. Higgins,Thor G. Theander +15 more
TL;DR: EPCR, which mediates the cytoprotective effects of activated protein C, is identified as the endothelial receptor for DC8 and DC13 PfEMP1, and it is shown that EPCR binding is mediated through the amino-terminal cysteine-rich interdomain region (CIDRα1) ofDC8 and group A Pf EMP1 subfamilies, and that CIDR α1 interferes with protein C binding to EPCC.
Journal ArticleDOI
Efficacy of RTS,S/AS01E Vaccine against Malaria in Children 5 to 17 Months of Age
Philip Bejon,John Lusingu,Ally Olotu,Amanda J. Leach,Marc Lievens,Johan Vekemans,Salum Mshamu,Trudie Lang,Jayne Gould,Marie-Claude Dubois,Marie-Ange Demoitié,Jean-Francois Stallaert,Preeti Vansadia,Terrell Carter,Patricia Njuguna,Ken Awuondo,Anangisye Malabeja,Omar Abdul,Samwel Gesase,Neema Mturi,Chris Drakeley,Barbara Savarese,Tonya Villafana,W. Ripley Ballou,Joe Cohen,Eleanor M. Riley,Martha M. Lemnge,Kevin Marsh,Lorenz von Seidlein +28 more
TL;DR: RTS,S/AS01E shows promise as a candidate malaria vaccine as compared with rabies vaccine in children in Kilifi, Kenya, and Korogwe, Tanzania, a target population for vaccine licensure.