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Ali Sharma
Researcher at Icahn School of Medicine at Mount Sinai
Publications - 15
Citations - 1212
Ali Sharma is an academic researcher from Icahn School of Medicine at Mount Sinai. The author has contributed to research in topics: Fragile X syndrome & FMR1. The author has an hindex of 10, co-authored 14 publications receiving 1063 citations. Previous affiliations of Ali Sharma include Cornell University & University of Tennessee.
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Journal ArticleDOI
Dysregulation of mTOR Signaling in Fragile X Syndrome
Ali Sharma,Charles A. Hoeffer,Yukihiro Takayasu,Yukihiro Takayasu,Takahiro Miyawaki,Takahiro Miyawaki,Sean M.J. McBride,Eric Klann,R. Suzanne Zukin +8 more
TL;DR: Elevated mTOR signaling may provide a functional link between overactivation of group I mGluRs and aberrant synaptic plasticity in the fragile X mouse, mechanisms relevant to impaired cognition in fragile X syndrome.
Journal ArticleDOI
Epigenetic modulation of inflammation and synaptic plasticity promotes resilience against stress in mice
Jun Wang,Jun Wang,Georgia E. Hodes,Hongxing Zhang,Song Zhang,Wei Zhao,Sam A. Golden,Weina Bi,Caroline Menard,Veronika Kana,Marylene Leboeuf,Marc Xie,Dana Bregman,Madeline L. Pfau,Meghan E. Flanigan,Adelaida Esteban-Fernández,Shrishailam Yemul,Ali Sharma,Lap Ho,Richard A. Dixon,Miriam Merad,Ming-Hu Han,Scott J. Russo,Giulio Maria Pasinetti,Giulio Maria Pasinetti +24 more
TL;DR: Two phytochemicals from bioactive dietary polyphenols are identified, shown to show their antidepressant effect in a rodent model of depression, and that this effect is mediated by epigenetic and anti-inflammatory mechanisms.
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Statin therapy for Alzheimer's disease: will it work?
Suzana Petanceska,Steven DeRosa,Vicki Olm,Nichole S. Diaz,Ali Sharma,Tara Thomas-Bryant,Karen Duff,Miguel A. Pappolla,Lorenzo M. Refolo +8 more
TL;DR: A study aimed at determining the effects of atorvastatin (LipitorR), a statin with the largest US market share, on brain Aβ deposition in the PSAPP transgenic mouse model of Alzheimer’s amyloidosis, indicates that Lipitor treatment markedly attenuates A β deposition in this animal model.
Journal Article
Trace copper levels in the drinking water, but not zinc or aluminum influence CNS Alzheimer-like pathology.
D. L. Sparks,Robert P. Friedland,Suzana Petanceska,Suzana Petanceska,Suzana Petanceska,Bernard G. Schreurs,J Shi,George Perry,Mark A. Smith,Ali Sharma,Steven DeRosa,C. Ziolkowski,Goran Stankovic +12 more
TL;DR: Water quality may have a significant influence on disease progression and Ab neuropathology in AD as well as administration of distilled water, which produced a reduction in the expected accumulation of Ab in three separate animal models.
Journal ArticleDOI
Changes in Apolipoprotein E Expression in Response to Dietary and Pharmacological Modulation of Cholesterol
Suzana Petanceska,Suzana Petanceska,Steven DeRosa,Ali Sharma,Nichole S. Diaz,Karen Duff,Karen Duff,Steven G. Tint,Lorenzo M. Refolo,Miguel A. Pappolla +9 more
TL;DR: It is found that chronic changes in total cholesterol in plasma lead to changes in ApoE mRNA levels in brain, and that long-term treatment of astrocytes and microglia with statins leads to a decrease in the cellular and/or secreted ApOE.