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Aline Bozec
Researcher at University of Erlangen-Nuremberg
Publications - 106
Citations - 4417
Aline Bozec is an academic researcher from University of Erlangen-Nuremberg. The author has contributed to research in topics: Arthritis & Medicine. The author has an hindex of 31, co-authored 84 publications receiving 3169 citations. Previous affiliations of Aline Bozec include Research Institute of Molecular Pathology & BBVA Compass.
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Journal ArticleDOI
Induction of osteoclastogenesis and bone loss by human autoantibodies against citrullinated vimentin
Ulrike Harre,Dan Georgess,Holger Bang,Aline Bozec,Roland Axmann,Elena Ossipova,Per-Johan Jakobsson,Wolfgang Baum,Falk Nimmerjahn,Eszter Szarka,Gabriella Sármay,G Krumbholz,Elena Neumann,René E. M. Toes,Hans Scherer,Anca I. Catrina,Lars Klareskog,Pierre Jurdic,Georg Schett +18 more
TL;DR: It is suggested that autoantibody formation in response to citrullinated vimentin directly induces bone loss, providing a link between the adaptive immune system and bone.
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Anti-inflammatory and immune-regulatory cytokines in rheumatoid arthritis
TL;DR: Anti-inflammatory cytokines counterbalance the chronic activation of innate and adaptive immune cells in rheumatoid arthritis anducing anti-inflammatory pathways and the resolution of inflammation is an attractive therapeutic option for patients with RA to achieve long-term disease control.
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Resolution of inflammation by interleukin-9-producing type 2 innate lymphoid cells
Simon Rauber,Markus Luber,Stefanie Weber,Lisa Maul,Alina Soare,Thomas Wohlfahrt,Neng-Yu Lin,Katharina Dietel,Aline Bozec,Martin Herrmann,Mark H. Kaplan,Benno Weigmann,Mario M. Zaiss,Ursula Fearon,Douglas J. Veale,Juan D. Cañete,Oliver Distler,Felice Rivellese,Costantino Pitzalis,Markus F. Neurath,Andrew N. J. McKenzie,Stefan Wirtz,Georg Schett,Jörg H W Distler,Andreas Ramming +24 more
TL;DR: Fostering IL-9-mediated ILC2 activation may offer a novel therapeutic approach inducing resolution of inflammation rather than suppression of inflammatory responses, as patients with rheumatoid arthritis in remission exhibited high numbers of IL- 9+ ILC 2s in joints and the circulation.
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Blockade of receptor activator of nuclear factor-κB (RANKL) signaling improves hepatic insulin resistance and prevents development of diabetes mellitus
Stefan Kiechl,Jürgen Wittmann,Andrea Giaccari,Michael Knoflach,Peter Willeit,Aline Bozec,Alexander R. Moschen,Giovanna Muscogiuri,Gian Pio Sorice,Trayana Kireva,Monika Summerer,Stefan Wirtz,Julia Luther,Dirk Mielenz,Ulrike Billmeier,Georg Egger,Agnes Mayr,Friedrich Oberhollenzer,Florian Kronenberg,Michael Orthofer,Josef M. Penninger,James B. Meigs,Enzo Bonora,Herbert Tilg,Johann Willeit,Georg Schett +25 more
TL;DR: Evidence is provided for a role of RANKL signaling in the pathogenesis of T2DM and if so, translation to the clinic may be feasible given current pharmacological strategies to lower RankL activity to treat osteoporosis.
Journal ArticleDOI
Osteoclast size is controlled by Fra-2 through LIF/LIF-receptor signalling and hypoxia
Aline Bozec,Latifa Bakiri,Astrid Hoebertz,Robert Eferl,Arndt F. Schilling,Vukoslav Komnenovic,Harald Scheuch,Matthias Priemel,Colin L. Stewart,Michael Amling,Erwin F. Wagner +10 more
TL;DR: It is shown that the Fos-related protein Fra-2 controls osteoclast survival and size, and these findings offer potential targets for the treatment of syndromes associated with increased osteoporosis.