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Alison E. Ringel
Researcher at Harvard University
Publications - 32
Citations - 1909
Alison E. Ringel is an academic researcher from Harvard University. The author has contributed to research in topics: NAD+ kinase & CD8. The author has an hindex of 16, co-authored 27 publications receiving 1181 citations. Previous affiliations of Alison E. Ringel include Johns Hopkins University & Johns Hopkins University School of Medicine.
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Journal ArticleDOI
Obesity Shapes Metabolism in the Tumor Microenvironment to Suppress Anti-Tumor Immunity
Alison E. Ringel,Jefte M. Drijvers,Jefte M. Drijvers,Gregory J. Baker,Alessia Catozzi,Alessia Catozzi,Juan Carlos García-Cañaveras,Brandon M. Gassaway,Brian C. Miller,Brian C. Miller,Vikram R. Juneja,Vikram R. Juneja,Thao H. Nguyen,Thao H. Nguyen,Shakchhi Joshi,Cong-Hui Yao,Haejin Yoon,Peter T. Sage,Peter T. Sage,Martin W. LaFleur,Martin W. LaFleur,Justin D. Trombley,Justin D. Trombley,Connor A. Jacobson,Zoltan Maliga,Steven P. Gygi,Peter K. Sorger,Joshua D. Rabinowitz,Arlene H. Sharpe,Arlene H. Sharpe,Marcia C. Haigis +30 more
TL;DR: It is demonstrated that high-fat diet (HFD)-induced obesity impairs CD8+ T cell function in the murine TME, accelerating tumor growth and blocking metabolic reprogramming by tumor cells in obese mice improves anti-tumor immunity.
Journal ArticleDOI
Metabolic recycling of ammonia via glutamate dehydrogenase supports breast cancer biomass
Jessica B. Spinelli,Jessica B. Spinelli,Haejin Yoon,Alison E. Ringel,Sarah Jeanfavre,Clary B. Clish,Marcia C. Haigis +6 more
TL;DR: In mice, ammonia accumulated in the tumor microenvironment and was used directly to generate amino acids through GDH activity, showing that ammonia is not only a secreted waste product but also a fundamental nitrogen source that can support tumor biomass.
Journal ArticleDOI
Histone demethylase KDM6A directly senses oxygen to control chromatin and cell fate.
Abhishek A. Chakraborty,Tuomas Laukka,Matti Myllykoski,Alison E. Ringel,Matthew A. Booker,Michael Y. Tolstorukov,Yuzhong Jeff Meng,Sam Meier,Rebecca B. Jennings,Amanda L. Creech,Zachary T. Herbert,Samuel K. McBrayer,Benjamin A. Olenchock,Jacob D. Jaffe,Marcia C. Haigis,Rameen Beroukhim,Rameen Beroukhim,Rameen Beroukhim,Sabina Signoretti,Peppi Koivunen,William G. Kaelin,William G. Kaelin +21 more
TL;DR: It is reported that hypoxia promotes histone methylation in a HIF- and 2-HG–independent manner and it is found that the H3K27 histone demethylase KDM6A/UTX, but not its paralog KDM5A, is oxygen sensitive.
Journal ArticleDOI
Mitochondrial Sirtuin Network Reveals Dynamic SIRT3-Dependent Deacetylation in Response to Membrane Depolarization
Wen Yang,Koji Nagasawa,Koji Nagasawa,Christian Münch,Yingjie Xu,Kyle Satterstrom,Seung Min Jeong,Sebastian D. Hayes,Mark P. Jedrychowski,F. Sejal Vyas,Elma Zaganjor,Virginia Guarani,Alison E. Ringel,Steven P. Gygi,J. Wade Harper,Marcia C. Haigis +15 more
TL;DR: The SIRT3-5 interaction network provides a framework for discovering novel biological functions regulated by mitochondrial sirtuins and identifies candidate sirtuin substrates, and uncovers a fundamental role for sequestration by ATP synthase in mitochondrial homeostasis.
Journal ArticleDOI
Structural basis for histone H2B deubiquitination by the SAGA DUB module.
Michael T. Morgan,Mahmood Haj-Yahya,Alison E. Ringel,Prasanthi Bandi,Ashraf Brik,Cynthia Wolberger +5 more
TL;DR: It is found that the DUB module deubiquitinates H2B both in the context of the nucleosome and in H2A/H2B dimers complexed with the histone chaperone, FACT, suggesting that SAGA could target H 2B at multiple stages of nucleosomes disassembly and reassembly during transcription.