M
Menna R. Clatworthy
Researcher at Wellcome Trust Sanger Institute
Publications - 174
Citations - 10024
Menna R. Clatworthy is an academic researcher from Wellcome Trust Sanger Institute. The author has contributed to research in topics: Immune system & Transplantation. The author has an hindex of 39, co-authored 136 publications receiving 7028 citations. Previous affiliations of Menna R. Clatworthy include Cambridge University Hospitals NHS Foundation Trust & Laboratory of Molecular Biology.
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Journal ArticleDOI
The Human Cell Atlas
Aviv Regev,Aviv Regev,Aviv Regev,Sarah A. Teichmann,Sarah A. Teichmann,Sarah A. Teichmann,Eric S. Lander,Eric S. Lander,Eric S. Lander,Ido Amit,Christophe Benoist,Ewan Birney,Bernd Bodenmiller,Bernd Bodenmiller,Peter J. Campbell,Peter J. Campbell,Piero Carninci,Menna R. Clatworthy,Hans Clevers,Bart Deplancke,Ian Dunham,James Eberwine,Roland Eils,Roland Eils,Wolfgang Enard,Andrew Farmer,Lars Fugger,Berthold Göttgens,Nir Hacohen,Nir Hacohen,Muzlifah Haniffa,Martin Hemberg,Seung K. Kim,Paul Klenerman,Paul Klenerman,Arnold R. Kriegstein,Ed S. Lein,Sten Linnarsson,Emma Lundberg,Emma Lundberg,Joakim Lundeberg,Partha P. Majumder,John C. Marioni,John C. Marioni,John C. Marioni,Miriam Merad,Musa M. Mhlanga,Martijn C. Nawijn,Mihai G. Netea,Garry P. Nolan,Dana Pe'er,Anthony Phillipakis,Chris P. Ponting,Stephen R. Quake,Wolf Reik,Wolf Reik,Wolf Reik,Orit Rozenblatt-Rosen,Joshua R. Sanes,Rahul Satija,Ton N. Schumacher,Alex K. Shalek,Alex K. Shalek,Alex K. Shalek,Ehud Shapiro,Padmanee Sharma,Jay W. Shin,Oliver Stegle,Michael R. Stratton,Michael J. T. Stubbington,Fabian J. Theis,Matthias Uhlen,Matthias Uhlen,Alexander van Oudenaarden,Allon Wagner,Fiona M. Watt,Jonathan S. Weissman,Barbara J. Wold,Ramnik J. Xavier,Nir Yosef,Nir Yosef,Human Cell Atlas Meeting Participants +81 more
TL;DR: An open comprehensive reference map of the molecular state of cells in healthy human tissues would propel the systematic study of physiological states, developmental trajectories, regulatory circuitry and interactions of cells, and also provide a framework for understanding cellular dysregulation in human disease.
Journal ArticleDOI
The adaptor MAVS promotes NLRP3 mitochondrial localization and inflammasome activation.
Naeha Subramanian,Kannan Natarajan,Menna R. Clatworthy,Menna R. Clatworthy,Ze Wang,Ronald N. Germain +5 more
TL;DR: It is shown that the mitochondria-associated adaptor molecule, MAVS, is required for optimal NLRP3 inflammasome activity, and this work reveals unexpected polygamous involvement of PYD/CARD-domain-containing adapters in innate immune signaling events.
Journal ArticleDOI
Phosphoinositide 3-Kinase δ Gene Mutation Predisposes to Respiratory Infection and Airway Damage
Ivan Angulo,Oscar Vadas,Fabien Garçon,Edward Banham-Hall,Vincent Plagnol,Timothy Ronan Leahy,Timothy Ronan Leahy,Helen Baxendale,Tanya I. Coulter,Tanya I. Coulter,James Curtis,Changxin Wu,Katherine G. Blake-Palmer,Olga Perisic,Deborah J. Smyth,Mailis Maes,Christine A Fiddler,Jatinder K. Juss,Deirdre Cilliers,Gašper Markelj,Anita Chandra,George Farmer,Anna Kielkowska,Jonathan Clark,Sven Kracker,Sven Kracker,Marianne Debré,Capucine Picard,Capucine Picard,Isabelle Pellier,Nada Jabado,James Morris,Gabriela Barcenas-Morales,Alain Fischer,Alain Fischer,Len R. Stephens,Phillip T. Hawkins,Jeffrey C. Barrett,Mario Abinun,Menna R. Clatworthy,Anne Durandy,Rainer Doffinger,Edwin R. Chilvers,Andrew J. Cant,Dinakantha S. Kumararatne,Klaus Okkenhaug,Roger L. Williams,Alison M. Condliffe,Sergey Nejentsev +48 more
TL;DR: Activated PI3K-δ syndrome (APDS), a PID associated with a dominant gain-of-function mutation in which lysine replaced glutamic acid at residue 1021 (E1021K) in the p110δ protein, the catalytic subunit of phosphoinositide 3-kinase δ (PI3Kδ), encoded by the PIK3CD gene is described.
Journal ArticleDOI
Single-cell transcriptomes from human kidneys reveal the cellular identity of renal tumors
Matthew D. Young,Thomas J. Mitchell,Thomas J. Mitchell,Thomas J. Mitchell,Felipe A. Vieira Braga,Maxine G. B. Tran,Benjamin J. Stewart,John R. Ferdinand,Grace Collord,Grace Collord,Grace Collord,Rachel A. Botting,Dorin-Mirel Popescu,Kevin W. Loudon,Roser Vento-Tormo,Emily Stephenson,Alex Cagan,Sarah J. Farndon,Sarah J. Farndon,Sarah J. Farndon,Martin Del Castillo Velasco-Herrera,Charlotte Guzzo,Nathan Richoz,Lira Mamanova,Tevita Aho,James N. Armitage,Antony C. P. Riddick,Imran Mushtaq,Stephen Farrell,Dyanne Rampling,James Nicholson,James Nicholson,Andrew Filby,Johanna Burge,Steven Lisgo,Patrick H. Maxwell,Susan Lindsay,Anne Y. Warren,Grant D. Stewart,Grant D. Stewart,Neil J. Sebire,Neil J. Sebire,Nicholas Coleman,Nicholas Coleman,Muzlifah Haniffa,Muzlifah Haniffa,Sarah A. Teichmann,Menna R. Clatworthy,Menna R. Clatworthy,Sam Behjati,Sam Behjati,Sam Behjati +51 more
TL;DR: It is determined that Wilms tumor, a pediatric kidney cancer, originates from aberrant fetal cells, whereas adult kidney cancers are likely derived from a specific subtype of proximal convoluted tubular cell.
Journal ArticleDOI
FcγRIIB in autoimmunity and infection: evolutionary and therapeutic implications
TL;DR: Increased understanding of the function of FcγRIIB has potentially far-reaching therapeutic implications, being involved in the mechanism of action of intravenous immunoglobulin, controlling the efficacy of monoclonal antibody therapy and providing a direct therapeutic target.