O
Olga Perisic
Researcher at Laboratory of Molecular Biology
Publications - 66
Citations - 9774
Olga Perisic is an academic researcher from Laboratory of Molecular Biology. The author has contributed to research in topics: Protein subunit & ESCRT. The author has an hindex of 43, co-authored 65 publications receiving 9005 citations. Previous affiliations of Olga Perisic include Medical Research Council & Boston College.
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Journal ArticleDOI
Structural Determinants of Phosphoinositide 3-kinase Inhibition by Wortmannin, LY294002, Quercetin, Myricetin, and Staurosporine
Edward H. Walker,Michael E. Pacold,Olga Perisic,Len R. Stephens,Philip T. Hawkins,Matthias P. Wymann,Roger L. Williams +6 more
TL;DR: Interestingly, LY294002 and the lead compound on which it was designed, quercetin, as well as the closely related flavonoid myricetin bind PI3K in remarkably different orientations that are related to each other by 180 degrees rotations.
Journal ArticleDOI
Crystal Structure and Functional Analysis of Ras Binding to Its Effector Phosphoinositide 3-Kinase γ
Michael E. Pacold,Sabine Suire,Olga Perisic,Samuel Lara-Gonzalez,Colin T. Davis,Edward H. Walker,Phillip T. Hawkins,Len R. Stephens,John F. Eccleston,Roger L. Williams +9 more
TL;DR: Ras activation of phosphoinositide 3-kinase (PI3K) is important for survival of transformed cells and it is found that PI3Kgamma is strongly and directly activated by H-Ras G12V in vivo or by GTPgammaS-loaded H- Ras in vitro.
Journal ArticleDOI
Crystal structure of a mammalian phosphoinositide-specific phospholipase C delta.
TL;DR: The 2.4-Å structure of phospholipase Cδ1 reveals a multidomain protein incorporating modules shared by many signalling proteins that suggests a mechanism for membrane attachment and Ca2+ -dependent hydrolysis of second-messenger precursors.
Journal ArticleDOI
Phosphoinositide 3-Kinase δ Gene Mutation Predisposes to Respiratory Infection and Airway Damage
Ivan Angulo,Oscar Vadas,Fabien Garçon,Edward Banham-Hall,Vincent Plagnol,Timothy Ronan Leahy,Timothy Ronan Leahy,Helen Baxendale,Tanya I. Coulter,Tanya I. Coulter,James Curtis,Changxin Wu,Katherine G. Blake-Palmer,Olga Perisic,Deborah J. Smyth,Mailis Maes,Christine A Fiddler,Jatinder K. Juss,Deirdre Cilliers,Gašper Markelj,Anita Chandra,George Farmer,Anna Kielkowska,Jonathan Clark,Sven Kracker,Sven Kracker,Marianne Debré,Capucine Picard,Capucine Picard,Isabelle Pellier,Nada Jabado,James Morris,Gabriela Barcenas-Morales,Alain Fischer,Alain Fischer,Len R. Stephens,Phillip T. Hawkins,Jeffrey C. Barrett,Mario Abinun,Menna R. Clatworthy,Anne Durandy,Rainer Doffinger,Edwin R. Chilvers,Andrew J. Cant,Dinakantha S. Kumararatne,Klaus Okkenhaug,Roger L. Williams,Alison M. Condliffe,Sergey Nejentsev +48 more
TL;DR: Activated PI3K-δ syndrome (APDS), a PID associated with a dominant gain-of-function mutation in which lysine replaced glutamic acid at residue 1021 (E1021K) in the p110δ protein, the catalytic subunit of phosphoinositide 3-kinase δ (PI3Kδ), encoded by the PIK3CD gene is described.
Journal ArticleDOI
Structural insights into phosphoinositide 3-kinase catalysis and signalling.
TL;DR: The 2.2 Å X-ray crystallographic structure of the catalytic subunit of PI3Kγ, the class I enzyme that is activated by heterotrimeric G-protein βγ subunits and Ras is reported.