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Alla Buzina
Researcher at University of Toronto
Publications - 10
Citations - 501
Alla Buzina is an academic researcher from University of Toronto. The author has contributed to research in topics: Cancer & Gene. The author has an hindex of 6, co-authored 8 publications receiving 452 citations.
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Journal ArticleDOI
Essential Gene Profiles in Breast, Pancreatic, and Ovarian Cancer Cells
Richard Marcotte,Kevin R. Brown,Fernando Suarez,Azin Sayad,Konstantina Karamboulas,Paul M. Krzyzanowski,Fabrice Sircoulomb,Mauricio Medrano,Yaroslav Fedyshyn,Judice L. Y. Koh,Dewald van Dyk,Bohdana Fedyshyn,Marianna Luhova,Glauber C. Brito,Franco J. Vizeacoumar,Frederick S. Vizeacoumar,Alessandro Datti,Dahlia Kasimer,Alla Buzina,Patricia Mero,Christine M. Misquitta,Josee Normand,Maliha Haider,Troy Ketela,Jeffrey L. Wrana,Robert Rottapel,Benjamin G. Neel,Jason Moffat +27 more
TL;DR: This study identified essential gene profiles in 72 breast, pancreatic, and ovarian cancer cell lines using a lentiviral shRNA library targeting ~16,000 genes and a newly developed, dynamic scoring approach, to facilitate the systematic identification of drivers, unanticipated synthetic lethal relationships, and functional vulnerabilities of these tumor types.
Journal ArticleDOI
A negative genetic interaction map in isogenic cancer cell lines reveals cancer cell vulnerabilities.
Franco J. Vizeacoumar,Franco J. Vizeacoumar,Roland Arnold,Frederick S. Vizeacoumar,Megha Chandrashekhar,Alla Buzina,Jordan T.F. Young,Jordan T.F. Young,Julian H. M. Kwan,Azin Sayad,Patricia Mero,Steffen Lawo,Steffen Lawo,Hiromasa Tanaka,Kevin R. Brown,Anastasia Baryshnikova,Anthony B. Mak,Yaroslav Fedyshyn,Yadong Wang,Glauber C. Brito,Dahlia Kasimer,Taras Makhnevych,Troy Ketela,Alessandro Datti,Mohan Babu,Andrew Emili,Laurence Pelletier,Laurence Pelletier,Jeff Wrana,Jeff Wrana,Zev A. Wainberg,Philip M. Kim,Robert Rottapel,Robert Rottapel,Robert Rottapel,Catherine A. O’Brien,Catherine A. O’Brien,Brenda J. Andrews,Charles Boone,Jason Moffat +39 more
TL;DR: The reference network suggests that many cancer vulnerabilities remain to be discovered through systematic derivation of a network of differentially essential genes in an isogenic cancer cell model.
Journal ArticleDOI
Infrequent Translation of a Nonsense Codon Is Sufficient to Decrease mRNA Level
Alla Buzina,Marc J. Shulman +1 more
TL;DR: It is shown that translation of Ter462 in the double mutant occurs at only approximately 4% the normal frequency, and that ter462 in cis with Ter3 can induce NMD, which is, translation of ter462 at this low (4%) frequency is sufficient to induce N MD.
Journal ArticleDOI
SMYD2 lysine methyltransferase regulates leukemia cell growth and regeneration after genotoxic stress
Adi Zipin-Roitman,Nasma Aqaqe,Muhammad Yassin,Shahar Biechonski,Mariam Amer,Mark F. van Delft,Mark F. van Delft,Olga I. Gan,Olga I. Gan,Sean P. McDermott,Sean P. McDermott,Alla Buzina,Troy Ketela,Liran I. Shlush,Liran I. Shlush,Stephanie Z. Xie,Stephanie Z. Xie,Veronique Voisin,Jason Moffat,Mark D. Minden,Mark D. Minden,John E. Dick,John E. Dick,Michael Milyavsky +23 more
TL;DR: It is proposed that the interplay between SMYD2 and SET7/9 levels shifts leukemia cells from growth to quiescence state that is associated with the higher resistance to DNA damaging agents and rationalize SET7 /9 pharmacological targeting in AML.
Journal ArticleDOI
Initiation of DNA replication at the human β-globin 3′ enhancer
TL;DR: It is concluded that a mammalian enhancer can cooperate with adjacent sequences to create an efficient replicator module and that the β-globin replicator has multiple initiation sites in three closely spaced replicator modules.