K
Konstantina Karamboulas
Researcher at University of Toronto
Publications - 3
Citations - 684
Konstantina Karamboulas is an academic researcher from University of Toronto. The author has contributed to research in topics: Deubiquitinating enzyme & Gene. The author has an hindex of 3, co-authored 3 publications receiving 615 citations.
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Journal ArticleDOI
Essential Gene Profiles in Breast, Pancreatic, and Ovarian Cancer Cells
Richard Marcotte,Kevin R. Brown,Fernando Suarez,Azin Sayad,Konstantina Karamboulas,Paul M. Krzyzanowski,Fabrice Sircoulomb,Mauricio Medrano,Yaroslav Fedyshyn,Judice L. Y. Koh,Dewald van Dyk,Bohdana Fedyshyn,Marianna Luhova,Glauber C. Brito,Franco J. Vizeacoumar,Frederick S. Vizeacoumar,Alessandro Datti,Dahlia Kasimer,Alla Buzina,Patricia Mero,Christine M. Misquitta,Josee Normand,Maliha Haider,Troy Ketela,Jeffrey L. Wrana,Robert Rottapel,Benjamin G. Neel,Jason Moffat +27 more
TL;DR: This study identified essential gene profiles in 72 breast, pancreatic, and ovarian cancer cell lines using a lentiviral shRNA library targeting ~16,000 genes and a newly developed, dynamic scoring approach, to facilitate the systematic identification of drivers, unanticipated synthetic lethal relationships, and functional vulnerabilities of these tumor types.
Journal ArticleDOI
A strategy for modulation of enzymes in the ubiquitin system.
Andreas Ernst,George V. Avvakumov,Jiefei Tong,Yihui Fan,Yanling Zhao,Philipp Alberts,Avinash Persaud,John R. Walker,Ana-Mirela Neculai,Dante Neculai,Andrew Vorobyov,Pankaj Garg,Linda G. Beatty,Pak-Kei Chan,Yu Chi Juang,Marie-Claude Landry,Christina Yeh,Christina Yeh,Elton Zeqiraj,Konstantina Karamboulas,Abdellah Allali-Hassani,Masoud Vedadi,Mike Tyers,Mike Tyers,Jason Moffat,Frank Sicheri,Frank Sicheri,Laurence Pelletier,Laurence Pelletier,Daniel Durocher,Daniel Durocher,Brian Raught,Daniela Rotin,Jianhua Yang,Michael Moran,Sirano Dhe-Paganon,Sirano Dhe-Paganon,Sachdev S. Sidhu +37 more
TL;DR: This work used massively diverse combinatorial libraries of ubiquitin variants to develop inhibitors of four deubiquitinases (DUBs) and analyzed the DUB-inhibitor complexes with crystallography to report a method to target the myriad enzymes that govern ubiquitination of protein substrates.
Journal ArticleDOI
A Lentiviral Functional Proteomics Approach Identifies Chromatin Remodeling Complexes Important for the Induction of Pluripotency
Anthony B. Mak,Zuyao Ni,Johannes A. Hewel,Ginny I. Chen,Guoqing Zhong,Konstantina Karamboulas,Kim Blakely,Sandra Smiley,Edyta Marcon,Denitza Roudeva,Joyce Li,Jonathan B. Olsen,Cuihong Wan,Thanuja Punna,Ruth Isserlin,Sergei V. Chetyrkin,Anne-Claude Gingras,Andrew Emili,Jack Greenblatt,Jason Moffat +19 more
TL;DR: A mammalian affinity purification and lentiviral expression (MAPLE) system for characterizing the subunit compositions of protein complexes is established and a role for the catalytic subunits of the SWI/SNF complex during somatic cell reprogramming is demonstrated.