M
Marianna Luhova
Researcher at University of Toronto
Publications - 1
Citations - 324
Marianna Luhova is an academic researcher from University of Toronto. The author has contributed to research in topics: Gene & Cancer. The author has an hindex of 1, co-authored 1 publications receiving 293 citations.
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Essential Gene Profiles in Breast, Pancreatic, and Ovarian Cancer Cells
Richard Marcotte,Kevin R. Brown,Fernando Suarez,Azin Sayad,Konstantina Karamboulas,Paul M. Krzyzanowski,Fabrice Sircoulomb,Mauricio Medrano,Yaroslav Fedyshyn,Judice L. Y. Koh,Dewald van Dyk,Bohdana Fedyshyn,Marianna Luhova,Glauber C. Brito,Franco J. Vizeacoumar,Frederick S. Vizeacoumar,Alessandro Datti,Dahlia Kasimer,Alla Buzina,Patricia Mero,Christine M. Misquitta,Josee Normand,Maliha Haider,Troy Ketela,Jeffrey L. Wrana,Robert Rottapel,Benjamin G. Neel,Jason Moffat +27 more
TL;DR: This study identified essential gene profiles in 72 breast, pancreatic, and ovarian cancer cell lines using a lentiviral shRNA library targeting ~16,000 genes and a newly developed, dynamic scoring approach, to facilitate the systematic identification of drivers, unanticipated synthetic lethal relationships, and functional vulnerabilities of these tumor types.