Mauricio Medrano

TL;DR: This study identified essential gene profiles in 72 breast, pancreatic, and ovarian cancer cell lines using a lentiviral shRNA library targeting ~16,000 genes and a newly developed, dynamic scoring approach, to facilitate the systematic identification of drivers, unanticipated synthetic lethal relationships, and functional vulnerabilities of these tumor types.

TL;DR: The results identify GEF-H1 as an amplifier of MAPK signaling and provide mechanistic insight into the progression of RAS mutant tumors.

TL;DR: It is demonstrated that HT-FC provides reproducible results, and the platform is used to identify cell surface antigens that are influenced by common cell preparation methods, and it is shown that multiple populations within complex samples can be simultaneously analyzed by co-staining of cells with lineage-specific antibodies.

TL;DR: It is reported that the tetraspanin CD151 contributes to survival of a subset of HGSC cell lines associated with a ZEB transcriptional program and supports the growth of HG SC tumors.

TL;DR: JAM-A expression is a robust prognostic biomarker of HGSC and may be used to discriminate tumors responsive to therapies targeting EMT and exhibited an enhanced epithelial to mesenchymal transition (EMT) signature.