Amal Alharbi

TL;DR: Spirooxindole 6a was found to be an efficient anti-proliferative agent towards both HepG2 and PC-3 cells and assessed for its apoptosis induction potential in HepG1 cells, where its pro-apoptotic impact was approved via the significant elevation in the Bax/Bcl-2 ratio and the expression levels of caspase-3.

TL;DR: The synthesis of two series of 3/4-(3-aryl-3-oxopropenyl) aminobenzenesulfonamides 5a-i and 6a-j as SLC-0111 enaminone congeners is reported, with interesting selectivity towards hCA IX over hCA I, II, IV and IX.

TL;DR: Molecular docking studies showed that the newly synthesised N1 -unsubstituted oxindole hybrids have comparable binding patterns in both CDK2 and GSK-3β, and the most potent compounds 5d–f caused cell cycle arrest in the G2/M phase in MCF-7 cells inducing cell apoptosis because of theCDK2/GSK-3 β inhibition.

TL;DR: In this paper, a potential novel inhibitor for SARS COV-2 2'-O-methyltransferase (nsp16) was identified, which is one of the most attractive targets in the virus life cycle, responsible for the viral RNA protection via a cap formation process.

TL;DR: The chemical composition of Syzygium cumini (Pomposia) essential oil via gas chromatography-mass spectrometry (GC/MS) analysis revealed the identification of fifty-three compounds representing about 91.22% of the total oil as discussed by the authors.