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Amanda Rumore
Researcher at Virginia Tech
Publications - 3
Citations - 437
Amanda Rumore is an academic researcher from Virginia Tech. The author has contributed to research in topics: Entry into host & Effector. The author has an hindex of 2, co-authored 3 publications receiving 404 citations. Previous affiliations of Amanda Rumore include Virginia Bioinformatics Institute.
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Journal ArticleDOI
External Lipid PI3P Mediates Entry of Eukaryotic Pathogen Effectors into Plant and Animal Host Cells
Shiv D. Kale,Biao Gu,Biao Gu,Daniel G. S. Capelluto,Daolong Dou,Emily R. Feldman,Amanda Rumore,Felipe D. Arredondo,Regina Hanlon,Isabelle Fudal,Thierry Rouxel,Christopher B. Lawrence,Weixing Shan,Brett M. Tyler +13 more
TL;DR: It is shown that effectors of another pathogen type, fungi, contain functional variants of the RXLR motif, and that the oomycete and fungal RX LR motifs enable binding to the phospholipid, phosphatidylinositol-3-phosphate (PI3P).
Journal ArticleDOI
Microbe-independent entry of oomycete RxLR effectors and fungal RxLR-like effectors into plant and animal cells is specific and reproducible
Brett M. Tyler,Shiv D. Kale,Qunqing Wang,Kai Tao,Helen R. Clark,Kelly Drews,Vincenzo Antignani,Amanda Rumore,Tristan Hayes,Jonathan M. Plett,Isabelle Fudal,Biao Gu,Qinghe Chen,Katharyn J. Affeldt,Erwin Berthier,Gregory J. Fischer,Daolong Dou,Weixing Shan,Nancy P. Keller,Francis Martin,Thierry Rouxel,Christopher B. Lawrence +21 more
TL;DR: New, more detailed data are presented that unambiguously demonstrate that the RxLR domain of Avr1b does show efficient and specific entry into soybean root cells and also into wheat leaf cells, a sign of microbe-independent entry into host and nonhost plant and animal cells.
Unraveling the Entry Mechanism of Oomycete and Fungal Effector Proteins into host cells
Shiv D. Kale,Amanda Rumore,Biao Gu,C. B. Shan,D. Lawrence,Daniel G. S. Capelluto,Brett M. Tyler +6 more
TL;DR: Effector entry into plant cells can be blocked by proteins and inositides that disrupt binding to PI-3-P, suggesting effector-blocking technologies that could be used in agriculturally important plant species.