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Amar Abderrahmani
Researcher at Imperial College London
Publications - 80
Citations - 3856
Amar Abderrahmani is an academic researcher from Imperial College London. The author has contributed to research in topics: Insulin & Apoptosis. The author has an hindex of 29, co-authored 69 publications receiving 3380 citations. Previous affiliations of Amar Abderrahmani include university of lille & University of Valenciennes and Hainaut-Cambresis.
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Inhibition of the glucose transporter SGLT2 with dapagliflozin in pancreatic alpha cells triggers glucagon secretion
Caroline Bonner,Julie Kerr-Conte,Valery Gmyr,Gurvan Queniat,Ericka Moerman,Julien Thevenet,Cédric Beaucamps,Nathalie Delalleau,Iuliana Popescu,Willy Malaisse,Abdullah Sener,Benoit Deprez,Amar Abderrahmani,Bart Staels,François Pattou +14 more
TL;DR: It is demonstrated that SGLT2 is expressed in glucagon-secreting alpha cells of the pancreatic islets, and dapagliflozin treatment further promotes glucagon secretion and hepatic gluconeogenesis in healthy mice, thereby limiting the decrease of plasma glucose induced by fasting.
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MicroRNA-9 Controls the Expression of Granuphilin/Slp4 and the Secretory Response of Insulin-producing Cells
Valérie Plaisance,Amar Abderrahmani,Amar Abderrahmani,Véronique Perret-Menoud,Patrick Jacquemin,Frédéric P. Lemaigre,Romano Regazzi +6 more
TL;DR: Evidence is provided that in insulin-producing cells adequate levels of mir-9 are mandatory for maintaining appropriate Granuphilin levels and optimal secretory capacity, and that silencing of Onecut-2 by RNA interference increases Gran Euphilin expression and mimics the effect of Mir-9 on stimulus-induced exocytosis.
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Alterations in microRNA expression contribute to fatty acid-induced pancreatic β-cell dysfunction
Pascal Lovis,E. Roggli,D. Ross Laybutt,Sonia Gattesco,Jiang-Yan Yang,Christian Widmann,Amar Abderrahmani,Romano Regazzi +7 more
TL;DR: The findings suggest that at least part of the detrimental effects of palmitate on β-cells is caused by alterations in the level of specific miRNAs.
Journal ArticleDOI
Involvement of microRNAs in the cytotoxic effects exerted by proinflammatory cytokines on pancreatic β-cells
E. Roggli,Aurore Britan,Sonia Gattesco,Nathalie Lin-Marq,Amar Abderrahmani,Paolo Meda,Romano Regazzi +6 more
TL;DR: MiR-21, miR-34a, andmiR-146a are identified as novel players in β-cell failure elicited in vitro and in vivo by proinflammatory cytokines, notably during the development of peri-insulitis that precedes overt diabetes in NOD mice.
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MicroRNAs contribute to compensatory β cell expansion during pregnancy and obesity.
Cécile Jacovetti,Amar Abderrahmani,Géraldine Parnaud,Jean-Christophe Jonas,Marie-Line Peyot,Marion Cornu,Ross Laybutt,Emmanuelle Meugnier,Sophie Rome,Bernard Thorens,Marc Prentki,Domenico Bosco,Romano Regazzi +12 more
TL;DR: Blockade of miR-338-3p in β cells using specific anti-miR molecules mimicked gene expression changes occurring during β cell mass expansion and resulted in increased proliferation and improved survival both in vitro and in vivo.