Amedea Mencarelli

TL;DR: Expressing the PML-RAR alpha protein in U937 myeloid precursor cells showed that they lost the capacity to differentiate under the action of different stimuli, acquired enhanced sensitivity to retinoic acid, and exhibited a higher growth rate consequent to diminished apoptotic cell death.

TL;DR: The high viral titer and the easy obtainment of homogeneously infected cell populations without drug selection procedures make PINCO an ideal vector for gene transfer of human primary hemopoietic cells.

TL;DR: It is found that PML is frequently overexpressed in Hodgkin and Reed-Sternberg cells of Hodgkin's disease, a tumor of cytokine-producing cells, and among solid tumors, overexpression of PML was frequently found in carcinomas of larynx and thyroid (papillary), epithelial thymomas, and Kaposi's sarcoma.

TL;DR: Results indicate that PML is involved in cell survival regulation and that the PML component of the fusion protein retains intact biological activity, thereby suggesting that the effects of PML/RARα on survival derive from the activation of the incorporated PML sequence.

TL;DR: It is demonstrated that NK cells can selectively detect the expression of heterologous genes, and this observations provide a general model of the NK cell–mediated control of viral infections.