A
Amelia J. Simpson
Researcher at University of California, San Diego
Publications - 3
Citations - 1046
Amelia J. Simpson is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Neutrophil extracellular traps & Pathogen. The author has an hindex of 2, co-authored 3 publications receiving 977 citations.
Papers
More filters
Journal ArticleDOI
DNase expression allows the pathogen group A Streptococcus to escape killing in neutrophil extracellular traps.
John T. Buchanan,Amelia J. Simpson,Ramy K. Aziz,George Y. Liu,Sascha A. Kristian,Malak Kotb,James R. Feramisco,Victor Nizet +7 more
TL;DR: A significant role for NETs in neutrophil-mediated innate immunity is demonstrated, and a novel therapeutic target against invasive GAS infection is identified.
Journal ArticleDOI
DNase Sda1 provides selection pressure for a switch to invasive group A streptococcal infection
Mark J. Walker,Andrew Hollands,Martina L. Sanderson-Smith,Jason N. Cole,Joshua K. Kirk,Anna Henningham,Jason D. McArthur,Katrin Dinkla,Ramy K. Aziz,Ramy K. Aziz,Rita Kansal,Amelia J. Simpson,John T. Buchanan,Gursharan S. Chhatwal,Malak Kotb,Victor Nizet,Victor Nizet +16 more
TL;DR: How bacteriophage-encoded GAS DNase (Sda1), which facilitates the pathogen's escape from neutrophil extracellular traps, serves as a selective force for covRS mutation is described, providing a paradigm whereby natural selection exerted by the innate immune system generates hypervirulent bacterial variants with increased risk of systemic dissemination.
Book ChapterDOI
Classification and Principals of Treatment
TL;DR: Treatment of intra-abdominal infection is multimodal including, most importantly, source control in conjunction with timely systemic antimicrobial therapy, resuscitation, and supportive care.