Ramy K. Aziz

TL;DR: A fully automated service for annotating bacterial and archaeal genomes that identifies protein-encoding, rRNA and tRNA genes, assigns functions to the genes, predicts which subsystems are represented in the genome, uses this information to reconstruct the metabolic network and makes the output easily downloadable for the user.

TL;DR: A significant role for NETs in neutrophil-mediated innate immunity is demonstrated, and a novel therapeutic target against invasive GAS infection is identified.

TL;DR: The discovery of a previously unidentified bacteriophage present in the majority of published human faecal metagenomes, which is referred to as crAssphage and predicted to have a Bacteroides host for this phage, consistent with Bactseroides-related protein homologues and a unique carbohydrate-binding domain encoded in the phage genome.

TL;DR: The recent updates to the PATRIC resource are reported, including new web-based comparative analysis tools, eight new services and the release of a command-line interface to access, query and analyze data.

TL;DR: How bacteriophage-encoded GAS DNase (Sda1), which facilitates the pathogen's escape from neutrophil extracellular traps, serves as a selective force for covRS mutation is described, providing a paradigm whereby natural selection exerted by the innate immune system generates hypervirulent bacterial variants with increased risk of systemic dissemination.