James R. Feramisco

TL;DR: It is reported here that micro-injection of an anti-CBP antiserum into fibroblasts can inhibit transcription from a cAMP responsive promoter, and proposed that CBP is recruited to the promoter through interaction with certain phosphorylated factors, and may thus play a critical role in the transmission of inductive signals from cell surface receptor to the transcriptional apparatus.

TL;DR: Microinjection of the proto-oncogenic and oncogenic forms of the human H-ras protein into living rat pheochromocytoma cells promoted the morphological differentiation of PC12 cells into neuron-like cells.

TL;DR: The stimulatory effect of the ras oncogene protein on ruffling and pinocytosis is dependent on the amount of injected protein and is accompanied by an apparent stimulation of phospholipase A2 activity, which may represent primary events in the mechanism of action of ras proteins.

TL;DR: A significant role for NETs in neutrophil-mediated innate immunity is demonstrated, and a novel therapeutic target against invasive GAS infection is identified.

TL;DR: Heparin treatment attenuates tumor metastasis in mice by inhibiting P-selectin-mediated interactions of platelets with carcinoma cell-surface mucin ligands, and it is suggested that heparin therapy for metastasis prevention in humans be revisited, with these mechanistic paradigms in mind.