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Amer M. Alanazi
Researcher at King Saud University
Publications - 112
Citations - 1597
Amer M. Alanazi is an academic researcher from King Saud University. The author has contributed to research in topics: Chemistry & Medicine. The author has an hindex of 20, co-authored 92 publications receiving 1080 citations.
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Journal ArticleDOI
Structure-based design of phthalimide derivatives as potential cyclooxygenase-2 (COX-2) inhibitors: anti-inflammatory and analgesic activities.
Amer M. Alanazi,Adel S. El-Azab,Adel S. El-Azab,Ibrahim A. Al-Suwaidan,Kamal E.H. ElTahir,Yousif A. Asiri,Naglaa I. Abdel-Aziz,Alaa A.-M. Abdel-Aziz,Alaa A.-M. Abdel-Aziz +8 more
TL;DR: A group of 30 cyclic imides (1-10a-c) was designed for evaluation as a selective COX-2 inhibitor and investigated in vivo for anti-inflammatory and analgesic activities and revealed a similar binding mode to SC-558, a selectiveCOX- 2 inhibitor.
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Evaluation of Self-Nanoemulsifying Drug Delivery Systems (SNEDDS) for Poorly Water-Soluble Talinolol: Preparation, in vitro and in vivo Assessment.
Mohsin Kazi,Mohammed Al-Swairi,Ajaz Ahmad,Mohammad Raish,Fars K. Alanazi,Mohamed M. Badran,Azmat Ali Khan,Amer M. Alanazi,Muhammad Delwar Hussain +8 more
TL;DR: Talinolol loaded SNEDDS formulations could be a potential oral pharmaceutical product with high drug-loading capacity, improved drug dissolution, increased gut permeation, reduced/no human RBC toxicity, and enhanced oral bioavailability.
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Design, synthesis and biological evaluation of some novel substituted quinazolines as antitumor agents.
Amer M. Alanazi,Alaa A.-M. Abdel-Aziz,Ibrahim A. Al-Suwaidan,Sami G. Abdel-Hamide,Taghreed Z. Shawer,Adel S. El-Azab,Adel S. El-Azab +6 more
TL;DR: A novel series of 6-chloro-2-p-tolylquinazolinone and substituted-(4-methylbenzamido)benzamide (1-20) were designed, synthesized and evaluated for their in-vitro antitumor activity and compound 16 was found to be a particularly active growth inhibitor of the renal cancer.
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Fluorescence spectroscopic and molecular docking studies of the binding interaction between the new anaplastic lymphoma kinase inhibitor crizotinib and bovine serum albumin
Ali S. Abdelhameed,Amer M. Alanazi,Ahmed H. Bakheit,Hany W. Darwish,Hazem A. Ghabbour,Ibrahim A. Darwish +5 more
TL;DR: It can be inferred that hydrophobic and electrostatic interactions are the major binding forces involved in formation of the CRB-BSA complex.
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Synthesis, antitumor activity and molecular docking study of some novel 3-benzyl-4(3H)quinazolinone analogues.
Ibrahim A. Al-Suwaidan,Alaa A.-M. Abdel-Aziz,Taghreed Z. Shawer,Rezk R. Ayyad,Amer M. Alanazi,Ahmad M. El-Morsy,Menshawy A. Mohamed,Naglaa I. Abdel-Aziz,Magda A.-A. El-Sayed,Adel S. El-Azab +9 more
TL;DR: The results of this study demonstrated that compounds 7 and 8 into ATP binding site of EGFR-TK which showed similar binding mode to erlotinib inhibited the growth of melanoma cell lines through inhibition of B-RAF kinase, similar to PLX4032.