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Amy J. Mathers
Researcher at University of Virginia Health System
Publications - 115
Citations - 4426
Amy J. Mathers is an academic researcher from University of Virginia Health System. The author has contributed to research in topics: Klebsiella pneumoniae & Medicine. The author has an hindex of 28, co-authored 95 publications receiving 3003 citations. Previous affiliations of Amy J. Mathers include University of Virginia.
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Journal ArticleDOI
The Role of Epidemic Resistance Plasmids and International High-Risk Clones in the Spread of Multidrug-Resistant Enterobacteriaceae
TL;DR: Escherichia coli sequence type 131 (ST131) and Klebsiella pneumoniae ST258 emerged in the 2000s as important human pathogens, have spread extensively throughout the world, and are responsible for the rapid increase in antimicrobial resistance among E. coli and K. pneumoniae strains.
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Infectious Diseases Society of America Guidance on the Treatment of Extended-Spectrum β-lactamase Producing Enterobacterales (ESBL-E), Carbapenem-Resistant Enterobacterales (CRE), and Pseudomonas aeruginosa with Difficult-to-Treat Resistance (DTR-P. aeruginosa).
Pranita D. Tamma,Samuel L. Aitken,Robert A. Bonomo,Amy J. Mathers,David van Duin,Cornelius J. Clancy +5 more
TL;DR: A panel of six infectious diseases specialists with expertise in managing antimicrobial resistant infections formulated common questions about the treatment of ESBL-E, CRE, and DTR-P.
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Effect and Safety of Meropenem–Vaborbactam versus Best-Available Therapy in Patients with Carbapenem-Resistant Enterobacteriaceae Infections: The TANGO II Randomized Clinical Trial
Richard G. Wunderink,Evangelos J. Giamarellos-Bourboulis,Galia Rahav,Amy J. Mathers,Matteo Bassetti,Jose A. Vazquez,Oliver A. Cornely,Joseph S. Solomkin,Tanaya Bhowmick,Jihad Bishara,George L. Daikos,Timothy Felton,Maria Jose Lopez Furst,Eun J. Kwak,Francesco Menichetti,Ilana Oren,Elizabeth Alexander,David E. Griffith,Olga Lomovskaya,Jeffery Loutit,Shu Zhang,Michael N. Dudley,Keith S Kaye +22 more
TL;DR: Monotherapy with meropenem–vaborbactam for CRE infection was associated with increased clinical cure, decreased mortality, and reduced nephrotoxicity compared with BAT.
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Nested Russian Doll-Like Genetic Mobility Drives Rapid Dissemination of the Carbapenem Resistance Gene blaKPC
Anna E. Sheppard,Nicole Stoesser,Daniel J. Wilson,Robert Sebra,Andrew Kasarskis,Luke Anson,Adam Giess,Louise Pankhurst,Alison Vaughan,Christopher J. Grim,Heather L. Cox,Anthony J. Yeh,Costi D. Sifri,A. Sarah Walker,Tim E. A. Peto,Derrick W. Crook,Amy J. Mathers +16 more
TL;DR: The findings demonstrate that nonclonal resistance gene dissemination can be extremely rapid, presenting significant challenges for public health surveillance and achieving effective control of antibiotic resistance.
Journal ArticleDOI
The Hospital Water Environment as a Reservoir for Carbapenem-Resistant Organisms Causing Hospital-Acquired Infections-A Systematic Review of the Literature.
Alice E Kizny Gordon,Amy J. Mathers,Elaine Y. L. Cheong,Thomas Gottlieb,Shireen Meher Kotay,A. Sarah Walker,Tim E. A. Peto,Derrick W. Crook,Nicole Stoesser +8 more
TL;DR: A combination of interventions seems to be most successful, including reinforcement of general infection control measures, alongside chemical disinfection, and it is likely that replacement of colonized water reservoirs may be required for long-term clearance.