A
Andrew Kasarskis
Researcher at Icahn School of Medicine at Mount Sinai
Publications - 133
Citations - 45617
Andrew Kasarskis is an academic researcher from Icahn School of Medicine at Mount Sinai. The author has contributed to research in topics: Population & Genome. The author has an hindex of 39, co-authored 127 publications receiving 39410 citations. Previous affiliations of Andrew Kasarskis include Mount Sinai Health System & Pacific Biosciences.
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Gene Ontology: tool for the unification of biology
M Ashburner,Catherine A. Ball,Judith A. Blake,David Botstein,Heather Butler,J. M. Cherry,Allan Peter Davis,Kara Dolinski,Selina S. Dwight,J.T. Eppig,Midori A. Harris,David P. Hill,Laurie Issel-Tarver,Andrew Kasarskis,Suzanna E. Lewis,John C. Matese,Joel E. Richardson,M. Ringwald,Gerald M. Rubin,Gavin Sherlock +19 more
TL;DR: The goal of the Gene Ontology Consortium is to produce a dynamic, controlled vocabulary that can be applied to all eukaryotes even as knowledge of gene and protein roles in cells is accumulating and changing.
Journal ArticleDOI
Mapping the Genetic Architecture of Gene Expression in Human Liver
Eric E. Schadt,Cliona Molony,Eugene Chudin,Ke-Ke Hao,Xia Yang,Pek Yee Lum,Andrew Kasarskis,Bin Zhang,Susanna Wang,Christine Suver,Jun Zhu,Joshua Millstein,Solveig K. Sieberts,John Lamb,Debraj GuhaThakurta,Jonathan M. J. Derry,John D. Storey,Iliana Avila-Campillo,Mark J Kruger,Jason M. Johnson,Carol A. Rohl,Atila van Nas,Margarete Mehrabian,Thomas A. Drake,Aldons J. Lusis,Ryan Smith,F. Peter Guengerich,Stephen C. Strom,Erin G. Schuetz,Thomas H. Rushmore,Roger G. Ulrich +30 more
TL;DR: This genome-wide association study of gene expression resulted in the detection of more than 6,000 associations between SNP genotypes and liver gene expression traits, where many of the corresponding genes identified have already been implicated in a number of human diseases.
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A window into third-generation sequencing
TL;DR: A new generation of single-molecule sequencing technologies (third-generation sequencing) that is emerging to fill this space, with the potential for dramatically longer read lengths, shorter time to result and lower overall cost.
Journal ArticleDOI
Origins of the E. coli Strain Causing an Outbreak of Hemolytic–Uremic Syndrome in Germany
David A. Rasko,Dale R. Webster,Jason W. Sahl,Ali Bashir,Nadia Boisen,Flemming Scheutz,Ellen E. Paxinos,Robert Sebra,Chen-Shan Chin,Dimitris Iliopoulos,Aaron Klammer,Paul Peluso,Lawrence Lee,Andrey Kislyuk,James H. Bullard,Andrew Kasarskis,Susanna Wang,John Eid,David R. Rank,Julia C. Redman,Susan R. Steyert,Jakob Frimodt-Møller,Carsten Struve,Andreas Petersen,Karen A. Krogfelt,James P. Nataro,Eric E. Schadt,Matthew K. Waldor +27 more
TL;DR: The findings suggest that horizontal genetic exchange allowed for the emergence of the highly virulent Shiga-toxin-producing enteroaggregative E. coli O104:H4 strain that caused the German outbreak, and highlight the way in which the plasticity of bacterial genomes facilitates the emerged of new pathogens.
Journal ArticleDOI
The origin of the Haitian cholera outbreak strain.
Chen-Shan Chin,Jon M. Sorenson,Jason B. Harris,William P. Robins,Richelle C. Charles,Roger R. Jean-Charles,James H. Bullard,Dale R. Webster,Andrew Kasarskis,Paul Peluso,Ellen E. Paxinos,Yoshiharu Yamaichi,Stephen B. Calderwood,John J. Mekalanos,Eric E. Schadt,Matthew K. Waldor,Matthew K. Waldor +16 more
TL;DR: The Haitian epidemic is probably the result of the introduction, through human activity, of a V. cholerae strain from a distant geographic source, and analysis of genomic variation of the Haitian isolates reveals a more distant relationship with circulating South American isolates.