Ana Chauca-Diaz

TL;DR: This work shows that DDR2 depletion increases sensitivity to anti–PD-1 treatment compared to monotherapy, and provides strong scientific rationale for targeting DDR2 in combination with PD-1 inhibitors.

TL;DR: It is shown across multiple murine tumor and metastasis models that CCR2 antagonism in combination with anti- PD-1 therapy leads to sensitization and enhanced tumor response over anti-PD-1 monotherapy and that enhanced treatment response correlates with enhanced CD8 + T cell recruitment and activation and a concomitant decrease in CD4 + regulatory T cell.

TL;DR: The role of the androgen receptor (AR) in the development of both experimental and human bladder cancer is less clear, with literature indicating that more advanced stage and grade disease are associated with reduced AR expression.

TL;DR: A novel and functionally important intracellular location of CD24 is defined; it is explained why surCD24- cells can remain aggressive, and the need to consider nucCD24 in both fundamental research and therapeutic development is highlighted.

TL;DR: The role of AGL loss in promoting carcinogenesis is supported and a rationale for evaluating Agl expression levels, or Agl Loss gene signature scores, in normal urothelium of populations at risk of BC development such as older male smokers is provided.