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James C. Costello

Researcher at Anschutz Medical Campus

Publications -  118
Citations -  9564

James C. Costello is an academic researcher from Anschutz Medical Campus. The author has contributed to research in topics: Cancer & Bladder cancer. The author has an hindex of 29, co-authored 104 publications receiving 7843 citations. Previous affiliations of James C. Costello include University of Colorado Boulder & Howard Hughes Medical Institute.

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Evolution of genes and genomes on the Drosophila phylogeny.

Andrew G. Clark, +429 more
- 08 Nov 2007 - 
TL;DR: These genome sequences augment the formidable genetic tools that have made Drosophila melanogaster a pre-eminent model for animal genetics, and will further catalyse fundamental research on mechanisms of development, cell biology, genetics, disease, neurobiology, behaviour, physiology and evolution.
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Wisdom of crowds for robust gene network inference

Daniel Marbach, +9 more
- 01 Aug 2012 - 
TL;DR: In this paper, the authors performed a comprehensive blind assessment of over 30 network inference methods on Escherichia coli, Staphylococcus aureus, Saccharomyces cerevisiae and in silico microarray data.

Wisdom of crowds for robust gene network inference

Daniel Marbach, +58 more
TL;DR: A comprehensive blind assessment of over 30 network inference methods on Escherichia coli, Staphylococcus aureus, Saccharomyces cerevisiae and in silico microarray data defines the performance, data requirements and inherent biases of different inference approaches, and provides guidelines for algorithm application and development.
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Next-Generation Machine Learning for Biological Networks

Diogo M. Camacho, +6 more
- 14 Jun 2018 - 
TL;DR: A primer on machine learning for life scientists is provided, including an introduction to deep learning, which could impact disease biology, drug discovery, microbiome research, and synthetic biology.
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Bactericidal Antibiotics Induce Mitochondrial Dysfunction and Oxidative Damage in Mammalian Cells

Sameer Kalghatgi, +13 more
- 03 Jul 2013 - 
TL;DR: Clinical relevant doses of bactericidal antibiotics—quinolones, aminoglycosides, and β-lactams—cause mitochondrial dysfunction and ROS overproduction in mammalian cells and these bactericidal antibiotic–induced effects lead to oxidative damage to DNA, proteins, and membrane lipids.