Ana Gomis

TL;DR: Results indicate that blockade of VR1 activity attenuates chemical and thermal nociception and hyperalgesia, supporting the tenet that this ionotropic receptor contributes to chemical and Thermal sensitivity and pain perception in vivo.

TL;DR: It has been suggested that the ribbon synapse of bipolar cells only supports transient exocytosis, but the results demonstrate that this synapse is specialized for the continuous secretion of neurotransmitter.

TL;DR: Results show that intact 2-arachidonoylglycerol and 1-arachesionoyl Glycerol are endogenous TRPV1 activators, contributing to phospholipase C-dependent TRP V1 channel activation and TRPv1-mediated antinociceptive signaling in the brain.

TL;DR: In this paper, G protein expression and membrane phosphatidylinositol 4,5-bisphosphate (PIP(2)) levels in intact and cell-free systems were manipulated to provide electrophysiological and biochemical evidence that inhibition of TASK channels by Galphaq-linked receptors proceeds unabated in the absence of phospholipase C (PLC) activity, and instead involves association of activated G protein subunits with the channels.

TL;DR: It is shown that hypoosmotic stimulation activates TRPC5 channels resulting in a large calcium influx, suggesting its role as a transducer of osmo‐mechanical stimuli.