Félix Viana

TL;DR: This work shows that LPS exerts fast, membrane delimited, excitatory actions via TRPA1, a transient receptor potential cation channel that is critical for transducing environmental irritant stimuli into nociceptor activity, and finds that pain and acute vascular reactions, including neurogenic inflammation (CGRP release) caused by LPS are primarily dependent onTRPA1 channel activation in nocICEptive sensory neurons, and develop independently of TLR4 activation.

TL;DR: This work identifies a population of cold-sensitive cultured mouse trigeminal ganglion neurons with a unique set of biophysical properties, and shows that cooling closes a background K+ channel, causing depolarization and firing that is limited by the slower reduction of a cationic inward current (Ih).

TL;DR: Different types of ion channels in ECs are described and their role in electrogenesis, Ca2+ signaling, vessel permeability, cell-cell communication, mechano-sensor functions, and pH and volume regulation is described.

TL;DR: Findings indicate that TRPM8-dependent impulse activity in corneal cold receptors contributes to regulating basal tear flow, and that warming of the cornea in humans also decreases tearing rate.

TL;DR: It is concluded that action potential repolarization and afterhyperpolarization are due to activation of pharmacologically distinct potassium conductances and that the mAHP requires the influx of extracellular calcium and is apamin sensitive.