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Ana M. Tomás
Researcher at University of Porto
Publications - 74
Citations - 2241
Ana M. Tomás is an academic researcher from University of Porto. The author has contributed to research in topics: Leishmania infantum & Trypanothione. The author has an hindex of 27, co-authored 70 publications receiving 1964 citations. Previous affiliations of Ana M. Tomás include Institute of Business & Medical Careers & International Centre for Genetic Engineering and Biotechnology.
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Journal ArticleDOI
P25 and P28 proteins of the malaria ookinete surface have multiple and partially redundant functions
Ana M. Tomás,Gabriele Margos,George Dimopoulos,Leo H.M. van Lin,Tania F. de Koning-Ward,Ria Sinha,Pietro Lupetti,Annette L. Beetsma,Maria del Carmen Rodriguez,Marianna Karras,Ariadne Hager,Jacqui Mendoza,Geoffrey Butcher,Fotis C. Kafatos,Chris J. Janse,Andrew P. Waters,Robert E. Sinden +16 more
TL;DR: It is shown that P25 and P28 share multiple functions during ookinete/oocyst development and the fact that Sko parasites are efficiently transmitted by the mosquito is a compelling reason for including both target antigens in transmission‐blocking vaccines.
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Peroxidases of trypanosomatids.
TL;DR: Observations point to the existence of an elaborate peroxide metabolism in trypanosomatids, which includes the unique feature of using reducing equivalents derived from trypanothione, a dithiol found exclusively in these protozoa.
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Complementary antioxidant defense by cytoplasmic and mitochondrial peroxiredoxins in Leishmania infantum.
Helena Carla Castro,Carla Sousa,Marta Santos,Anabela Cordeiro-da-Silva,Leopold Flohé,Ana M. Tomás +5 more
TL;DR: Evidence is shown that both enzymes are active as peroxidases in vivo and that they have complementary roles in parasite protection against oxidative stress.
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Transfection of the primate malaria parasite Plasmodium knowlesi using entirely heterologous constructs
Anna M. van der Wel,Ana M. Tomás,Clemens H. M. Kocken,Pawan Malhotra,Chris J. Janse,Andrew P. Waters,Alan W. Thomas +6 more
TL;DR: Stable transfection of Plasmodium knowlesi is reported on, indicating that common signals control gene expression in phylogenetically distant PlasModium species.
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Overexpression of Cruzipain, the Major Cysteine Proteinase of Trypanosoma cruzi, is Associated with Enhanced Metacyclogenesis
TL;DR: Phenotypic analysis of the transformed parasites showed that they had an enhanced ability to undergo metacyclogenesis and suggested an association between overexpression of cruzipain and increased resistance to the cysteine proteinase inhibitor Cbz-Phe- Phe-CHN2 (where CbZ is benzoyloxycarbonyl).