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Alexander B. Niculescu
Researcher at Indiana University
Publications - 84
Citations - 5092
Alexander B. Niculescu is an academic researcher from Indiana University. The author has contributed to research in topics: Bipolar disorder & Candidate gene. The author has an hindex of 34, co-authored 79 publications receiving 4699 citations. Previous affiliations of Alexander B. Niculescu include United States Department of Veterans Affairs & Indiana University – Purdue University Indianapolis.
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Journal ArticleDOI
Effects of p21(Cip1/Waf1) at both the G1/S and the G2/M cell cycle transitions: pRB is a critical determinant in blocking DNA replication and in preventing endoreduplication
TL;DR: The data show that at physiological levels of accumulation, p21, in addition to its role in negatively regulating the G1/S transition, contributes to regulation of the G2/M transition, and the primary target of the Cip/Kip family of inhibitors leading to efficient G1 arrest as well as to blockade of DNA replication from either G1 or G2 phase is the pRb regulatory system.
Journal ArticleDOI
Convergent functional genomics of schizophrenia: from comprehensive understanding to genetic risk prediction.
M Ayalew,Helen Le-Niculescu,Daniel F. Levey,N Jain,B. Changala,S D Patel,Evan A. Winiger,A. Breier,Anantha Shekhar,Richard Amdur,Daniel L. Koller,John I. Nurnberger,Aiden Corvin,Mark A. Geyer,Ming T. Tsuang,Daniel R. Salomon,Nicholas J. Schork,Ayman H. Fanous,Michael Conlon O'Donovan,Alexander B. Niculescu,Alexander B. Niculescu +20 more
TL;DR: This work maps the genomic and biological landscape for schizophrenia, providing leads towards a better understanding of illness, diagnostics and therapeutics, and reveals the significant genetic overlap with other major psychiatric disorder domains, suggesting the need for improved nosology.
Journal ArticleDOI
Candidate genes, pathways and mechanisms for bipolar (manic–depressive) and related disorders: an expanded convergent functional genomics approach
Corey A. Ogden,M E Rich,M E Rich,Nicholas J. Schork,Martin P. Paulus,Martin P. Paulus,Mark A. Geyer,Mark A. Geyer,James B. Lohr,James B. Lohr,R Kuczenski,R Kuczenski,Alexander B. Niculescu,Alexander B. Niculescu +13 more
TL;DR: Data from a relevant pharmacogenomic mouse model and human data combined with human data suggest that more primitive molecular mechanisms involved in pleasure and pain may have been recruited by evolution to play a role in higher mental functions such as mood.
Journal Article
Erratum: Effects of p21(Cip1/Waf1) at both the G1/S and the G2/M cell cycle transitions: pRb is a critical determinant in blocking DNA replication and in preventing endoreduplication (Molecular and Cellular Biology 18:1 (629))
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Oxidative mechanisms and tardive dyskinesia.
TL;DR: Because evidence has continued to accumulate for increased oxidative damage from antipsychotic medications, but less so for the effectiveness of vitamin E, especially in cases of long-standing tardive dyskinesia, alternative antioxidant approaches to the condition may be warranted.