A
Andrea Cappon
Researcher at University of Padua
Publications - 25
Citations - 1791
Andrea Cappon is an academic researcher from University of Padua. The author has contributed to research in topics: Immune system & Innate immune system. The author has an hindex of 14, co-authored 23 publications receiving 1522 citations. Previous affiliations of Andrea Cappon include Medical Research Council & University of Florence.
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Journal ArticleDOI
Differential Ly-6C expression identifies the recruited macrophage phenotype, which orchestrates the regression of murine liver fibrosis
Prakash Ramachandran,Antonella Pellicoro,Madeleine A. Vernon,Luke Boulter,Rebecca L. Aucott,Aysha Ali,Stephen N. Hartland,Victoria K. Snowdon,Andrea Cappon,Timothy T. Gordon-Walker,Mike J. Williams,Donald R. Dunbar,Jonathan R. Manning,Nico van Rooijen,Jonathan A. Fallowfield,Stuart J. Forbes,John P. Iredale +16 more
TL;DR: The restorative macrophage phenotype was recapitulated in vitro by the phagocytosis of cellular debris with associated activation of the ERK signaling cascade, offering a therapeutic strategy to this orphan pathological process.
Journal ArticleDOI
The neutrophil-activating protein of Helicobacter pylori promotes Th1 immune responses
Amedeo Amedei,Andrea Cappon,Gaia Codolo,Anna Cabrelle,Alessandra Polenghi,Marisa Benagiano,Elisabetta Tasca,Annalisa Azzurri,Mario Milco D'Elios,Gianfranco Del Prete,Marina de Bernard +10 more
TL;DR: Data indicate HP-NAP as an important factor of H. pylori able to elicit cells of the innate immune system to produce IL-12 and IL-23, and they suggest it as a new tool for promoting Th1 immune responses.
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Borrelia burgdorferi NapA-Driven Th17 Cell Inflammation in Lyme Arthritis
Gaia Codolo,Amedeo Amedei,Allen C. Steere,Elena Papinutto,Andrea Cappon,Alessandra Polenghi,Marisa Benagiano,Silvia Rossi Paccani,Vittorio Sambri,Gianfranco Del Prete,Cosima T. Baldari,Giuseppe Zanotti,Cesare Montecucco,Mario Milco D'Elios,Marina de Bernard +14 more
TL;DR: Findings indicate that NapA of B burgdorferi is able to drive the expression of IL-6,IL-1beta, IL-23, and TGFbeta by cells of the innate immune system and to elicit a synovial fluid Th17 cell response that might play a crucial role in the pathogenesis of Lyme arthritis.
Journal ArticleDOI
The neutrophil-activating protein of Helicobacter pylori (HP-NAP) as an immune modulating agent.
TL;DR: HP-NAP is a key factor driving Th1 inflammation in H. pylori infection and may be a new tool for future therapeutic strategies aimed at redirecting Th2 into Th1 responses, for example in atopy, vaccinology and cancer immunotherapy.
Journal ArticleDOI
MERTK rs4374383 polymorphism affects the severity of fibrosis in non-alcoholic fatty liver disease
Salvatore Petta,Luca Valenti,Fabio Marra,Stefania Grimaudo,Claudio Tripodo,Elisabetta Bugianesi,Calogero Cammà,Andrea Cappon,Vito Di Marco,Giovanni Di Maira,Paola Dongiovanni,Raffaela Rametta,Alessandro Gulino,Enrico Mozzi,Emanuele Orlando,Marco Maggioni,Rosaria Maria Pipitone,Silvia Fargion,Antonio Craxì +18 more
TL;DR: The rs4374383 AA genotype, associated with lower intrahepatic expression of MERTK, is protective against F2-F4 fibrosis in patients with NAFLD and may involve modulation of HSC activation.