J
Jonathan A. Fallowfield
Researcher at University of Edinburgh
Publications - 87
Citations - 5811
Jonathan A. Fallowfield is an academic researcher from University of Edinburgh. The author has contributed to research in topics: Cirrhosis & Fibrosis. The author has an hindex of 27, co-authored 76 publications receiving 4330 citations. Previous affiliations of Jonathan A. Fallowfield include Medical Research Council & Queen's University.
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Journal ArticleDOI
Liver fibrosis and repair: immune regulation of wound healing in a solid organ
TL;DR: This Review focuses on recent advances in liver fibrosis research as a paradigm for wound healing in solid organs and the role of the immune system in regulating and balancing this response.
Journal ArticleDOI
Differential Ly-6C expression identifies the recruited macrophage phenotype, which orchestrates the regression of murine liver fibrosis
Prakash Ramachandran,Antonella Pellicoro,Madeleine A. Vernon,Luke Boulter,Rebecca L. Aucott,Aysha Ali,Stephen N. Hartland,Victoria K. Snowdon,Andrea Cappon,Timothy T. Gordon-Walker,Mike J. Williams,Donald R. Dunbar,Jonathan R. Manning,Nico van Rooijen,Jonathan A. Fallowfield,Stuart J. Forbes,John P. Iredale +16 more
TL;DR: The restorative macrophage phenotype was recapitulated in vitro by the phagocytosis of cellular debris with associated activation of the ERK signaling cascade, offering a therapeutic strategy to this orphan pathological process.
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Resolving the fibrotic niche of human liver cirrhosis at single cell level
Prakash Ramachandran,Ross Dobie,John R. Wilson-Kanamori,Elena Dora,Beth E. P. Henderson,N T Luu,N T Luu,Jordan R. Portman,Kylie P. Matchett,M Brice,John A. Marwick,Richard S Taylor,Mirjana Efremova,Roser Vento-Tormo,Neil O. Carragher,Timothy J. Kendall,Jonathan A. Fallowfield,Ewen M Harrison,David R. Mole,David R. Mole,Stephen J. Wigmore,Stephen J. Wigmore,Philip N. Newsome,Philip N. Newsome,Christopher J. Weston,Christopher J. Weston,John P. Iredale,Frank Tacke,Jeffrey W. Pollard,Jeffrey W. Pollard,Chris P. Ponting,John C. Marioni,John C. Marioni,John C. Marioni,Sarah A. Teichmann,Sarah A. Teichmann,Sarah A. Teichmann,Neil C. Henderson +37 more
TL;DR: Analysis of transcriptomes of more than 100,000 single human cells yields molecular definitions for non-parenchymal cell types that are found in healthy and cirrhotic human liver, and identifies markers for scar-associated macrophages and endothelial cells.
Journal ArticleDOI
Coffee consumption and health: umbrella review of meta-analyses of multiple health outcomes
Robin Poole,Oliver J. Kennedy,Paul Roderick,Jonathan A. Fallowfield,Peter C. Hayes,Julie Parkes +5 more
TL;DR: Coffee consumption seems generally safe within usual levels of intake, with summary estimates indicating largest risk reduction for various health outcomes at three to four cups a day, and more likely to benefit health than harm.
Journal ArticleDOI
Spontaneous recovery from micronodular cirrhosis: Evidence for incomplete resolution associated with matrix cross-linking
Razao Issa,Xiaoying Zhou,Christothea M. Constandinou,Jonathan A. Fallowfield,Harry Millward-Sadler,Marianna D. A. Gaça,Emma Sands,Ibnauf Suliman,Nathan Trim,Andreas Knorr,Michael J. P. Arthur,R. Christopher Benyon,John P. Iredale +12 more
TL;DR: Recovery from comparatively advanced cirrhosis is possible and results in remodeling from a micronodular Cirrhosis to a macronsodular cir rhosis, which is suggested to be limited by tTg-mediated matrix cross-linking and a failure of HSC apoptosis.