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Andrea Sottoriva
Researcher at Institute of Cancer Research
Publications - 97
Citations - 8915
Andrea Sottoriva is an academic researcher from Institute of Cancer Research. The author has contributed to research in topics: Cancer & Somatic evolution in cancer. The author has an hindex of 31, co-authored 87 publications receiving 6969 citations. Previous affiliations of Andrea Sottoriva include University of Amsterdam & University of Southern California.
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Journal ArticleDOI
Intratumor heterogeneity in human glioblastoma reflects cancer evolutionary dynamics
Andrea Sottoriva,Andrea Sottoriva,Andrea Sottoriva,Inmaculada Spiteri,Sara Grazia Maria Piccirillo,Anestis Touloumis,V. Peter Collins,John C. Marioni,Christina Curtis,Colin Watts,Simon Tavaré,Simon Tavaré,Simon Tavaré +12 more
TL;DR: The genome-wide architecture of intratumor variability in GB is revealed across multiple spatial scales and patient-specific patterns of cancer evolution, with consequences for treatment design.
Journal ArticleDOI
Patient-derived organoids model treatment response of metastatic gastrointestinal cancers
Georgios Vlachogiannis,Somaieh Hedayat,Alexandra Vatsiou,Yann Jamin,Javier Fernández-Mateos,Khurum Khan,Khurum Khan,Andrea Lampis,Katherine Eason,Ian Said Huntingford,Rosemary Burke,Mihaela Rata,Dow-Mu Koh,Dow-Mu Koh,Nina Tunariu,Nina Tunariu,David J. Collins,Sanna Hulkki-Wilson,Chanthirika Ragulan,Inmaculada Spiteri,Sing Yu Moorcraft,Ian Chau,Sheela Rao,David Watkins,Nicos Fotiadis,Maria Antonietta Bali,Maria Antonietta Bali,Mahnaz Darvish-Damavandi,Hazel Lote,Hazel Lote,Zakaria Eltahir,Elizabeth C Smyth,Ruwaida Begum,Paul A. Clarke,Jens C. Hahne,Mitchell Dowsett,Johann S. de Bono,Paul Workman,Anguraj Sadanandam,Matteo Fassan,Owen J. Sansom,Suzanne A. Eccles,Naureen Starling,Chiara Braconi,Chiara Braconi,Andrea Sottoriva,Simon P. Robinson,David Cunningham,Nicola Valeri,Nicola Valeri +49 more
TL;DR: Responses to anticancer agents ex vivo in organoids and PDO-based orthotopic mouse tumor xenograft models with the responses of the patients in clinical trials are compared to suggest that PDOs can recapitulate patient responses in the clinic and could be implemented in personalized medicine programs.
Journal ArticleDOI
A Big Bang model of human colorectal tumor growth
Andrea Sottoriva,Haeyoun Kang,Zhicheng Ma,Trevor A. Graham,Matthew P. Salomon,Junsong Zhao,Paul Marjoram,Kimberly D. Siegmund,Michael F. Press,Darryl Shibata,Christina Curtis +10 more
TL;DR: A 'Big Bang' model is presented, whereby tumors grow predominantly as a single expansion producing numerous intermixed subclones that are not subject to stringent selection and where both public and most detectable private alterations arise early during growth.
Journal ArticleDOI
ANTARES: the first undersea neutrino telescope
M. Ageron,Juanan Aguilar,I. Al Samarai,Arnauld Albert,Fabrizio Ameli,Michel André,M. Anghinolfi,Gisela Anton,S. Anvar,Miguel Ardid,K. Arnaud,Elie Aslanides,A. C.S. Assis Jesus,Tri L. Astraatmadja,J-J. Aubert,R. Auer,E. Barbarito,B. Baret,S. Basa,M. Bazzotti,Yvonne Becherini,J. Beltramelli,A. Bersani,V. Bertin,S. Beurthey,S. Biagi,Ciro Bigongiari,M. Billault,R. Blaes,C. Bogazzi,N. de Botton,Manuel Bou-Cabo,B. Boudahef,M.C. Bouwhuis,A. M. Brown,Jürgen Brunner,Jose Busto,L. Caillat,A. Calzas,Francisco Camarena,A. Capone,L. Caponetto,C. Cârloganu,G. Carminati,E. Carmona,J. Carr,P. H. Carton,B. Cassano,E. Castorina,S. Cecchini,A. Ceres,Th. Chaleil,Ph. Charvis,P. Chauchot,Tommaso Chiarusi,M. Circella,Chantal Compère,R. Coniglione,X. Coppolani,A. Cosquer,Heide Costantini,N. Cottini,P. Coyle,S. Cuneo,C. Curtil,C. D'Amato,G. Damy,R. van Dantzig,G. De Bonis,G. Decock,M. P. Decowski,I. Dekeyser,E. Delagnes,F. Desages-Ardellier,Anne Deschamps,J.-J. Destelle,F. Di Maria,B. Dinkespiler,C. Distefano,J.-L. Dominique,C. Donzaud,C. Donzaud,Damien Dornic,Damien Dornic,Q. Dorosti,J. F. Drogou,Doriane Drouhin,F. Druillole,Dominique Durand,R. Durand,Thomas Eberl,U. Emanuele,J.J. Engelen,J.-P. Ernenwein,Stephanie Escoffier,E. Falchini,S. Favard,F. Fehr,F. Feinstein,M. Ferri,S. Ferry,C. Fiorello,V. Flaminio,F. Folger,U. Fritsch,J.-L. Fuda,S. Galatà,S. Galeotti,F. Gensolen,G. Giacomelli,C. Gojak,J.P. Gómez-González,P. Goret,Kay Graf,G. Guillard,G. Halladjian,Gregory David Hallewell,H. van Haren,B. Hartmann,A.J. Heijboer,E. Heine,Yann Hello,S. Henry,Juan José Hernández-Rey,B. Herold,J. Hößl,J. Hogenbirk,C. C. Hsu,J.R. Hubbard,M. Jaquet,M. Jaspers,M. de Jong,D. Jourde,Matthias Kadler,Nasser Kalantar-Nayestanaki,Oleg Kalekin,Alexander Kappes,Timo Karg,S. Karkar,M. Karolak,U. F. Katz,P. Keller,Pierre Kestener,E. Kok,H. Kok,P.M. Kooijman,P.M. Kooijman,C. Kopper,A. Kouchner,W. Kretschmer,A. Kruijer,S. Kuch,Vladimir Kulikovskiy,D. Lachartre,H. Lafoux,P. Lagier,Robert Lahmann,C. Lahonde-Hamdoun,Patrick Lamare,Guillaume Lambard,J.-C. Languillat,Giuseppina Larosa,J. Lavalle,Y. Le Guen,H. Le Provost,A. LeVanSuu,Dominique Lefèvre,T. Legou,G. Lelaizant,C. Lévéque,G. Lim,D. Lo Presti,H. Loehner,S. Loucatos,F. Louis,F. Lucarelli,V. Lyashuk,P. Magnier,S. Mangano,A. Marcel,M. Marcelin,Annarita Margiotta,J.A. Martínez-Mora,R. Masullo,F. Mazéas,Alain Mazure,Athina Meli,M. Melissas,E. Migneco,M. Mongelli,Teresa Montaruli,M. Morganti,L. Moscoso,Holger Motz,Mario Musumeci,C. L. Naumann,M. Naumann-Godo,M. Neff,V. Niess,Gerardus Nooren,J.E.J. Oberski,C. Olivetto,Nathalie Palanque-Delabrouille,D. Palioselitis,Riccardo Papaleo,G.E. Păvălaş,K. Payet,P. Payre,H. Peek,J. Petrovic,Paolo Piattelli,N. Picot-Clemente,C. Picq,Y. Piret,J. Poinsignon,V. Popa,T. Pradier,E. Presani,G. Prono,C. Racca,G. Raia,J. van Randwijk,Diego Real,C. Reed,F. Réthoré,P. Rewiersma,Giorgio Riccobene,C. Richardt,R. Richter,J.S. Ricol,V. Rigaud,V. Roca,K. Roensch,Jean-Francois Rolin,A. Rostovtsev,A. Rottura,J. Roux,M. Rujoiu,M. Ruppi,G.V. Russo,F. Salesa,K. Salomon,Paolo Sapienza,F. Schmitt,F. M. Schöck,J. P. Schuller,F. Schüssler,D. Sciliberto,Rezo Shanidze,E. Shirokov,Francesco Simeone,Andrea Sottoriva,A. Spies,T. Spona,Maurizio Spurio,Jos Steijger,Th. Stolarczyk,K. Streeb,L. Sulak,M. Taiuti,Christian Tamburini,Charling Tao,L. A. M. Tasca,G. Terreni,D. Tezier,Simona Toscano,F. Urbano,P. Valdy,B. Vallage,V. Van Elewyck,G. Vannoni,Manuela Vecchi,Manuela Vecchi,G. Venekamp,B. Verlaat,P. Vernin,E. Virique,G. de Vries,R. van Wijk,G. Wijnker,G. Wobbe,E. A. De Wolf,Y. Yakovenko,H. Yepes,D. Zaborov,H. Zaccone,J.D. Zornoza,J. Zúñiga +287 more
TL;DR: The ANTARES Neutrino Telescope was completed in May 2008 and is the first operational neutrino telescope in the Mediterranean Sea as mentioned in this paper, where the main purpose of the detector is to perform neutrinos astronomy and the apparatus also offers facilities for marine and Earth sciences.
Journal ArticleDOI
Identification of neutral tumor evolution across cancer types.
TL;DR: It is demonstrated that neutral tumor evolution results in a power-law distribution of the mutant allele frequencies reported by next-generation sequencing of tumor bulk samples, and this result provides a new way to interpret existing cancer genomic data and to discriminate between functional and non-functional intratumoral heterogeneity.