P
Pravin Kumar Ankush Jagtap
Researcher at European Bioinformatics Institute
Publications - 28
Citations - 606
Pravin Kumar Ankush Jagtap is an academic researcher from European Bioinformatics Institute. The author has contributed to research in topics: RNA & RNA-binding protein. The author has an hindex of 10, co-authored 22 publications receiving 443 citations. Previous affiliations of Pravin Kumar Ankush Jagtap include Indian Institute of Technology Kanpur & Technische Universität München.
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Journal ArticleDOI
Structural model of the dimeric Parkinson's protein LRRK2 reveals a compact architecture involving distant interdomain contacts.
Giambattista Guaitoli,Francesco Raimondi,Francesco Raimondi,Bernd K Gilsbach,Bernd K Gilsbach,Bernd K Gilsbach,Yacob Gomez-Llorente,Egon Deyaert,Fabiana Renzi,Xianting Li,Adam Schaffner,Pravin Kumar Ankush Jagtap,Karsten Boldt,Felix von Zweydorf,Katja Gotthardt,Donald D. Lorimer,Zhenyu Yue,Alex B. Burgin,Nebojsa Janjic,Michael Sattler,Wim Versées,Marius Ueffing,Iban Ubarretxena-Belandia,Arjan Kortholt,Christian Johannes Gloeckner +24 more
TL;DR: This work has modeled the 3D structure of dimeric, full-length LRRK2 by combining domain-based homology models with multiple experimental constraints provided by chemical cross-linking combined with mass spectrometry, negative-stain EM, and small-angle X-ray scattering, and reveals dimeric L RRK2 has a compact overall architecture with a tight, multidomain organization.
Journal ArticleDOI
Leucine-rich repeat kinase 2 binds to neuronal vesicles through protein interactions mediated by its C-terminal WD40 domain.
Giovanni Piccoli,Giovanni Piccoli,Franco Onofri,Maria Daniela Cirnaru,Christoph J. O. Kaiser,Pravin Kumar Ankush Jagtap,Andreas Kastenmüller,Francesca Pischedda,Antonella Marte,Felix von Zweydorf,Andreas Vogt,Andreas Vogt,Florian Giesert,Lifeng Pan,Flavia Antonucci,Christina Kiel,Mingjie Zhang,Sevil Weinkauf,Michael Sattler,Carlo Sala,Michela Matteoli,Marius Ueffing,Marius Ueffing,Christian Johannes Gloeckner,Christian Johannes Gloeckner +24 more
TL;DR: A domain-based pulldown approach combined with mass spectrometric analysis identified LRRK2 as being part of a highly specific protein network involved in synaptic vesicle trafficking, and demonstrated a critical role of the WD40 domain within L RRK2 function.
Journal ArticleDOI
Structure, dynamics and RNA binding of the multi-domain splicing factor TIA-1.
Iren Wang,Janosch Hennig,Pravin Kumar Ankush Jagtap,Miriam Sonntag,Juan Valcárcel,Michael Sattler +5 more
TL;DR: The role of binding avidity and the contributions of the T-cell intracellular antigen-1 RRMs for recognition of pyrimidine-rich RNAs are unraveled.
Journal ArticleDOI
Segmental, Domain-Selective Perdeuteration and Small-Angle Neutron Scattering for Structural Analysis of Multi-Domain Proteins.
Miriam Sonntag,Pravin Kumar Ankush Jagtap,Bernd Simon,Marie-Sousai Appavou,Arie Geerlof,Ralf Stehle,Frank Gabel,Janosch Hennig,Michael Sattler +8 more
TL;DR: It is shown that domain-selective perdeuteration combined with contrast-matched small-angle neutron scattering (SANS), SAXS and computational modeling provides valuable information to precisely define relative domain arrangements in RBP TIA-1.
Journal ArticleDOI
Structural Basis for EarP-Mediated Arginine Glycosylation of Translation Elongation Factor EF-P.
Ralph Krafczyk,Jakub Macošek,Pravin Kumar Ankush Jagtap,Daniel Gast,Swetlana Wunder,Prithiba Mitra,Amit Kumar Jha,Jürgen Rohr,Anja Hoffmann-Röder,Kirsten Jung,Janosch Hennig,Jürgen Lassak +11 more
TL;DR: The crystal structure of EarP is solved and the first molecular insights into arginine glycosylation are provided, which lays the basis for targeted-inhibitor design against Pseudomonas aeruginosa infection.