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Andreas Kispert
Researcher at Hannover Medical School
Publications - 193
Citations - 22971
Andreas Kispert is an academic researcher from Hannover Medical School. The author has contributed to research in topics: Wnt signaling pathway & Mesenchyme. The author has an hindex of 69, co-authored 183 publications receiving 21176 citations. Previous affiliations of Andreas Kispert include Carnegie Institution for Science & Harvard University.
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β‐catenin is a target for the ubiquitin–proteasome pathway
TL;DR: It is shown that ubiquitination of β‐catenin is greatly reduced in Wnt‐expressing cells, providing the first evidence that the ubiquitin–proteasome degradation pathway may act downstream of GSK3β in the regulation ofβ‐ catenin.
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Female development in mammals is regulated by Wnt-4 signalling
TL;DR: In the mammalian embryo, both sexes are initially morphologically indistinguishable: specific hormones are required for sex-specific development but the establishment of sexual dimorphism is under the control of both local and systemic signals.
Journal ArticleDOI
A primary requirement for nodal in the formation and maintenance of the primitive streak in the mouse
Frank L. Conlon,Karen M. Lyons,Norma T. Takaesu,Katrin S. Barth,Andreas Kispert,Bernhard Herrmann,Elizabeth J. Robertson +6 more
TL;DR: Data presented in this report demonstrate the involvement of a TGF beta-related molecule in axis formation in mammals and provides direct evidence that the proviral insertion causes a loss of function mutation.
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Mutations in INVS encoding inversin cause nephronophthisis type 2, linking renal cystic disease to the function of primary cilia and left-right axis determination.
Edgar A. Otto,Bernhard Schermer,Tomoko Obara,John F. O'Toole,Karl S. Hiller,Adelheid M. Mueller,Rainer G. Ruf,Julia Hoefele,Frank Beekmann,Daniel Landau,John W. Foreman,Judith A. Goodship,Tom Strachan,Andreas Kispert,Matthias T.F. Wolf,Marie F. Gagnadoux,Hubert Nivet,Corinne Antignac,Gerd Walz,Iain A. Drummond,Thomas Benzing,Friedhelm Hildebrandt +21 more
TL;DR: The interaction and colocalization in cilia of inversin, nephrocystin and β-tubulin connect pathogenetic aspects of NPHP to PKD, to primary cilia function and to left-right axis determination.
Journal ArticleDOI
The centrosomal protein nephrocystin-6 is mutated in Joubert syndrome and activates transcription factor ATF4
John A. Sayer,John A. Sayer,Edgar A. Otto,John F. O'Toole,Gudrun Nürnberg,Michael A. Kennedy,Christian Becker,Hans Christian Hennies,Juliana Helou,Massimo Attanasio,Blake V. Fausett,Boris Utsch,Hemant Khanna,Yan Liu,Iain A. Drummond,Isao Kawakami,Takehiro Kusakabe,Motoyuki Tsuda,Li Ma,Hwankyu Lee,Ronald G. Larson,Susan J. Allen,Christopher J. Wilkinson,Erich A. Nigg,Chengchao Shou,Concepción Lillo,David S. Williams,Bernd Hoppe,Markus J. Kemper,Thomas J. Neuhaus,Melissa A. Parisi,Ian A. Glass,Marianne Petry,Andreas Kispert,Joachim Gloy,Athina Ganner,Gerd Walz,Xueliang Zhu,Daniel Goldman,Peter Nürnberg,Anand Swaroop,Michel R. Leroux,Friedhelm Hildebrandt +42 more
TL;DR: These findings help establish the link between centrosome function, tissue architecture and transcriptional control in the pathogenesis of cystic kidney disease, retinal degeneration, and central nervous system development.