Athina Ganner

TL;DR: Fuid flow increases inversin levels in ciliated tubular epithelial cells and seems to regulate this crucial switch between Wnt signaling pathways during renal development, implying that an inhibition of canonical Wnt behavior is required for normal renal development.

TL;DR: These findings help establish the link between centrosome function, tissue architecture and transcriptional control in the pathogenesis of cystic kidney disease, retinal degeneration, and central nervous system development.

TL;DR: Inversin is essential for recruiting Dishevelled to the plasma membrane in response to activated Frizzled, a crucial step in planar cell polarity signaling.

TL;DR: This clinical finding suggests that the gene products, nephrocystin-5 and nephropin-6, participate in overlapping signaling pathways to maintain photoreceptor homeostasis, and conformational changes seem to regulate the interaction of nephROcyst in-6 with its binding partners.

TL;DR: It is shown that Inversin is essential for Xenopus pronephros formation, involving two distinct and opposing forms of cell movements, and defective tubule morphogenesis seems to contribute to the renal pathology observed in patients with nephronophthisis type II.