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Bernhard Schermer
Researcher at University of Cologne
Publications - 155
Citations - 12563
Bernhard Schermer is an academic researcher from University of Cologne. The author has contributed to research in topics: Podocyte & Cilium. The author has an hindex of 45, co-authored 141 publications receiving 11205 citations. Previous affiliations of Bernhard Schermer include Goethe University Frankfurt & University of Freiburg.
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Journal ArticleDOI
A mammalian microRNA expression atlas based on small RNA library sequencing.
Pablo Landgraf,Mirabela Rusu,Robert L. Sheridan,Alain Sewer,Alain Sewer,Nicola Iovino,Alexei A. Aravin,Sébastien Pfeffer,Amanda J. Rice,Alice O. Kamphorst,Markus Landthaler,Carolina Lin,Nicholas D. Socci,Leandro C. Hermida,Valerio Fulci,Sabina Chiaretti,Robin Foà,Julia Schliwka,Uta Fuchs,Astrid Novosel,Roman-Ulrich Müller,Roman-Ulrich Müller,Bernhard Schermer,Ute Bissels,Jason M. Inman,Quang Phan,Minchen Chien,David B. Weir,Ruchi Choksi,Gabriella De Vita,Daniela Frezzetti,Hans Ingo Trompeter,Veit Hornung,Grace Teng,Gunther Hartmann,Miklós Palkovits,Roberto Di Lauro,Peter Wernet,Giuseppe Macino,Charles E. Rogler,James W. Nagle,Jingyue Ju,F. Nina Papavasiliou,Thomas Benzing,Peter Lichter,Wayne Tam,Michael J. Brownstein,Andreas Bosio,Arndt Borkhardt,James J. Russo,Chris Sander,Mihaela Zavolan,Mihaela Zavolan,Thomas Tuschl +53 more
TL;DR: A relatively small set of miRNAs, many of which are ubiquitously expressed, account for most of the differences in miRNA profiles between cell lineages and tissues.
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Inversin, the gene product mutated in nephronophthisis type II, functions as a molecular switch between Wnt signaling pathways
Matias Simons,Joachim Gloy,Athina Ganner,Axel Bullerkotte,Mikhail Bashkurov,Corinna Krönig,Bernhard Schermer,Thomas Benzing,Olga A. Cabello,Andreas Jenny,Marek Mlodzik,Bozena Polok,Wolfgang Driever,Tomoko Obara,Gerd Walz +14 more
TL;DR: Fuid flow increases inversin levels in ciliated tubular epithelial cells and seems to regulate this crucial switch between Wnt signaling pathways during renal development, implying that an inhibition of canonical Wnt behavior is required for normal renal development.
Journal ArticleDOI
Mutations in INVS encoding inversin cause nephronophthisis type 2, linking renal cystic disease to the function of primary cilia and left-right axis determination.
Edgar A. Otto,Bernhard Schermer,Tomoko Obara,John F. O'Toole,Karl S. Hiller,Adelheid M. Mueller,Rainer G. Ruf,Julia Hoefele,Frank Beekmann,Daniel Landau,John W. Foreman,Judith A. Goodship,Tom Strachan,Andreas Kispert,Matthias T.F. Wolf,Marie F. Gagnadoux,Hubert Nivet,Corinne Antignac,Gerd Walz,Iain A. Drummond,Thomas Benzing,Friedhelm Hildebrandt +21 more
TL;DR: The interaction and colocalization in cilia of inversin, nephrocystin and β-tubulin connect pathogenetic aspects of NPHP to PKD, to primary cilia function and to left-right axis determination.
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Nephrin and CD2AP associate with phosphoinositide 3-OH kinase and stimulate AKT-dependent signaling.
Tobias B. Huber,Björn Hartleben,Jeong Kim,Miriam Schmidts,Bernhard Schermer,Alexander Keil,Lotti Egger,Rachel L. Lecha,Christoph Borner,Hermann Pavenstädt,Andrey S. Shaw,Gerd Walz,Thomas Benzing +12 more
TL;DR: A novel role is revealed for the slit diaphragm proteins nephrin, CD2AP, and podocin and it is demonstrated that these three proteins, in addition to their structural functions, initiate PI3K/AKT-dependent signal transduction in glomerular podocytes.
Journal ArticleDOI
Exome Capture Reveals ZNF423 and CEP164 Mutations, Linking Renal Ciliopathies to DNA Damage Response Signaling
Moumita Chaki,Rannar Airik,Amiya K. Ghosh,Rachel H. Giles,Rui Chen,Gisela G. Slaats,Hui Wang,Toby W. Hurd,Weibin Zhou,Andrew Cluckey,Heon Yung Gee,Gokul Ramaswami,Chen Jei Hong,Bruce A. Hamilton,Igor Cervenka,Ranjani Sri Ganji,Vitezslav Bryja,Vitezslav Bryja,Heleen H. Arts,Jeroen van Reeuwijk,Machteld M. Oud,Stef J.F. Letteboer,Ronald Roepman,Hervé Husson,Oxana Ibraghimov-Beskrovnaya,Takayuki Yasunaga,Gerd Walz,Lorraine Eley,John A. Sayer,Bernhard Schermer,Max C. Liebau,Thomas Benzing,Stéphanie Le Corre,Iain A. Drummond,Sabine Janssen,Susan J. Allen,Sivakumar Natarajan,John F. O’Toole,Massimo Attanasio,Sophie Saunier,Corinne Antignac,Robert K. Koenekoop,Huanan Ren,Irma Lopez,Ahmet Nayir,Corinne Stoetzel,Hélène Dollfus,Rustin Massoudi,Joseph G. Gleeson,Sharon P. Andreoli,Dan G. Doherty,Anna Lindstrad,Christelle Golzio,Nicholas Katsanis,Lars Pape,Emad B. Abboud,Ali A. Al-Rajhi,Richard A. Lewis,Heymut Omran,Eva Y.-H. P. Lee,Shaohui Wang,JoAnn Sekiguchi,Rudel A. Saunders,Colin A. Johnson,Elizabeth Garner,K. Vanselow,Jens S. Andersen,Joseph Shlomai,Gudrun Nürnberg,Peter Nürnberg,Shawn Levy,Agata Smogorzewska,Edgar A. Otto,Friedhelm Hildebrandt,Friedhelm Hildebrandt +74 more
TL;DR: It is shown that knockdown of CEP164 or ZNF423 causes sensitivity to DNA damaging agents and that cep164 knockdown in zebrafish results in dysregulated DDR and an NPHP-RC phenotype, and these findings link degenerative diseases of the kidney and retina, disorders of increasing prevalence, to mechanisms of DDR.